ID A0A3P9MZ96_POERE Unreviewed; 2003 AA.
AC A0A3P9MZ96;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Dedicator of cytokinesis 11 {ECO:0000313|Ensembl:ENSPREP00000002649.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000002649.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000002649.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000002649.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 8081.ENSPREP00000002649; -.
DR Ensembl; ENSPRET00000002697.1; ENSPREP00000002649.1; ENSPREG00000001054.1.
DR GeneTree; ENSGT00940000155658; -.
DR OMA; YDHYIPL; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000001054; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF81; DEDICATOR OF CYTOKINESIS PROTEIN 11; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 161..268
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 640..814
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1549..1976
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 271..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2003 AA; 227803 MW; DD3E1AD10D8DA065 CRC64;
MSEVRKFTKR LSKPGTAAEV RQSVSEAVRS TVDLVEQPKI IEPLDYEAVV FQRKAQIHSD
PHRDLLLCPA DDVSESQISR QRRTVVPSVP QNAEQEARSL FAKECIKMYN TDWHVINYKY
EAYSGDFRML PSKGLKTDKL PTHVFEIDED DTASLCSQRG GILKQGWLQK ANINSSLSVS
MRVFKRRYFY LSQLPDGSYI LNSYKEEKNC KETKGSIYLD SCIDVVQSPK MRRNGFELKM
QDRYSHFLAA DSEAEMEDWV STLKQALQSA AEAVPDKRNG AEPLDFNTGH QGKGEGLQES
QGRSLHSELM KYVRETDQLN KINRNEGRQK LFSLDPETQR LDFSGIEPDV KPFEERFGRR
IMVSCHDLTF SLQGCVNEKA DGVLTNVEPF FICLALFDLS KNCKISADFH VDLNPPCVRE
MLTDTSGQLS PSSDSEGGGS GDDLVAAIHP LPPLTSSLVF CSQGIFSVTN PHADIFLVAR
VEKVLQNGIT HCTEPYIKTS DTNKTAQKVL KAAKQTCQRL GHYRMPFAWA AKQVFKDAQG
SLDMDGKFSP LYRQDSSKIS TDDLLKLLAD SRKPEKSKLQ IIPGQLNVTI ECVPPDFSNT
VTSSYIPIKP FEDGCERVSV EIEEFLPVEA KYNYPFTTYK NQLYIYPLQL KYDNQKTFTK
ARNIAVCMQF KDSDEEGSVP LKCIYGKPGD SLFANGAYAA VLHHNQSPDF YDEVKIELPV
HVHDRHHILF TFYHVSCESS SKASSKKRDG VESLVGYSWM PLLKDGRMQS SELQLPVAAA
LPAGYLCQDS RKSQPDIKWV ENAKSLFKVK SRVASTIYPQ DLHLHKFFQH CQLMKTMSDG
NPAELIKYLK CLHAVETHIV ITFLPTVLMQ LFEVLTAATK ETHEIAVNSL RVIIHIVSKC
QEEGLEHYLR SFVKYVFVAN APASGSSSTT HEVLATAVTA TLKQTADFNT SNKLLRYSWF
FFETMAKSMA QYLQEGNRMK MPRPQRFPDS FHQALQSLVL SIMPHITIRH MEIPEEARSI
NLSLASLIKR CMTFMNRGFA FGLVNHYMCH FSLKDPKVLT EMKFEFLMAV CNHEHFIPLN
LPMAFGRTKL QRVQDLIPYA TELFGPVEQS LEFSLTEEYC RNHFMVGLLM REVAEALQQG
PEVRQLAVSI LKNLLIKHAM DDRYTAFKNQ QARICTLYLP LYELLYQNLK QLSAQPQMSS
LGLGLNVSSF LQRRGSTMSS SAGPPAGRLG LYEIKGLLFS FLHIVKTLSE ETLMAYWSKI
SPQDIMNFLS LLESQDVCVS KLFSSDRKSQ TMPAMRYNRA SLMQTKIHQF STMETSLTLN
IGAGPSEAEI HHQALLEGNI STEVSLSVLD ILSLFSQCFK TQLLDGDGHN PLMRKVFDVY
LTFLKVGQSE AAIRHVFAAL RGFINKFPSV LFKGRVTLCE DLCCEVLKCC VSKLAVLRAE
ASALLYLLMR NNYEFTKRKT FLRTHLQIII AVSQLISDVA LTGSSRFQES LSIINNFANS
DKAMKSTAFP GEVKGLTMRI RTVLMATAQM REHEKDPEML LDLQYSLALS YASTPELRRT
WLDSMARAHL KNGDLSEAAM CYVHVAALVA EYLYRKKLFP CGLTAFKKVT LNIEEEAAMK
EDTGMQDVYY TEEVLVEHLE VCVEALWKAE RYELITHIAK LIIPIYEKRH EYEKLSRLYD
TLHRAYNKIM EVIQSGRRLL GTYFRVAFYG QGFFEEEDGK EYIYKEPKLT GLSEISQRLL
TLYGDKFGTE NVKIIQDSNK VNPKELDSRF AYVQVTFVKP YFDEKEAPEK KTDFEKCHNI
RNFVFETPYT LSGKKHGGVE EQCKRRTVLT TANTFPYVKK RIEVKGERQV ELKPVDVAID
EMRARTAELT KLCSSQEVDM IQLQLKLQGC VSVQVNAGPM AYARAFLDDS KSNSSGSKKV
KELKEVFRRF VEACSMALDI NERIIKEDQF EYHEGLKSNF KDMVKELSDI IHEQIYQEDM
MRSLLQNSLH VFRAISGTST DMS
//
