ID A0A3P9MZA3_POERE Unreviewed; 2341 AA.
AC A0A3P9MZA3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Protein transport protein sec16 {ECO:0000256|RuleBase:RU364101};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000002641.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000002641.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000002641.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the organization of the endoplasmic reticulum
CC exit sites (ERES), also known as transitional endoplasmic reticulum
CC (tER). Required for secretory cargo traffic from the endoplasmic
CC reticulum to the Golgi apparatus. {ECO:0000256|RuleBase:RU364101}.
CC -!- SUBUNIT: SEC16A and SEC16B are each present in multiple copies in a
CC heteromeric complex. {ECO:0000256|RuleBase:RU364101}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU364101}.
CC -!- SIMILARITY: Belongs to the SEC16 family.
CC {ECO:0000256|ARBA:ARBA00005927, ECO:0000256|RuleBase:RU364101}.
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DR RefSeq; XP_008421920.1; XM_008423698.1.
DR Ensembl; ENSPRET00000002689.1; ENSPREP00000002641.1; ENSPREG00000001938.1.
DR GeneID; 103473441; -.
DR CTD; 9919; -.
DR GeneTree; ENSGT00940000159324; -.
DR OrthoDB; 1361743at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000001938; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:UniProt.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:InterPro.
DR GO; GO:0048208; P:COPII vesicle coating; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd09233; ACE1-Sec16-like; 1.
DR Gene3D; 1.25.40.1030; -; 1.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR024880; Sec16.
DR InterPro; IPR024340; Sec16_CCD.
DR PANTHER; PTHR13402:SF13; PROTEIN TRANSPORT PROTEIN SEC16A; 1.
DR PANTHER; PTHR13402; RGPR-RELATED; 1.
DR Pfam; PF12932; Sec16; 1.
DR Pfam; PF12931; Sec16_C; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU364101};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|RuleBase:RU364101};
KW Golgi apparatus {ECO:0000256|RuleBase:RU364101};
KW Membrane {ECO:0000256|RuleBase:RU364101};
KW Protein transport {ECO:0000256|RuleBase:RU364101};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transport {ECO:0000256|RuleBase:RU364101}.
FT DOMAIN 1387..1484
FT /note="Sec16 central conserved"
FT /evidence="ECO:0000259|Pfam:PF12932"
FT DOMAIN 1557..1791
FT /note="Ancestral coatomer element 1 Sec16/Sec31"
FT /evidence="ECO:0000259|Pfam:PF12931"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1280..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1843..1881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1996..2032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2046..2196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2206..2225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2235..2341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1067
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1094
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1996..2020
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2046..2087
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2097..2114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2126..2157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2158..2182
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2239..2272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2292..2334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2341 AA; 253439 MW; C11561BB6823FBE2 CRC64;
MQPTPRAGPP RASLPNMTGR IRPQKHATAV TATMPPPTQP ITDPFAFGRA QPSMAVGGLP
TIPNSSPPQM QAPPNAMYSQ LGSGLPPQPQ LLENVPAAVA GPPAQPLSGV TLFTPRGTPS
AGVFPSPSPT GYVSANNEQD YFNSRDPAAT MSTDASHTSP APSNTLFNQD FQAHHLGHPL
PFQPLPPSSS STQWAPDHSS RPPSVQNYFQ PTVDPPARPS NIPPQSQMYP SHSQSPHHSA
PTPPAYSGHP QIRPPAPLQN PLAAASSLLP DPNEPQHLNS HFQTQSYFSQ SSAPHDLWFN
QPVQDSGYHQ MGTGPSHPQP PTDSAGSPHV SSTGHGPVSQ PVPSSIPATD AYGQESGTIS
MFFKGSDVEN EETLADERNK TLNGVAASFQ HNSNPPSHSS HSDLTIDYQG VSVPDHSRLP
YMNESSHHLQ GHIQKLPDND FDHVENLECV PNQEVLPNES SSSAAAAIAA CNPVDQFEAG
PNLETPDSVP RPMRSASVSS NYSNLSHGSG TGSRRHQGVE GTFIQQESPR LADNPNASSA
AAAAAAGGYF EQIDTSPSGD VGVQGSAEHM WHPTPSPPKP TGIFQASANS SFEPVRSHGV
GVRPAEVDKA KMVAEGGSDS TSGNLEQPPD NMENIFGPGQ APAPSPGDGL SSQTHSVVHP
HSRPSSRAFG ANRPCESPAT TLWAQSDPTS LGTNFLLAPA ALTVFAPLRE PSADVIQPPE
DCPLDLQASQ RAQTATQQHS ENLENPPKVS DAEPVDSQSG LGYASLLVSS SLHQPVLIAP
PVSNYSVIPP SIPTPSSTQT NHGEVVFPER PPAQGLGASI SQPSALPSKQ NPLFSSGSAA
FCSSAPNQGP LNLTRDKTVG APSEITTPPH SQPVHPPLSR GQSLGAESHS TVNSQPVSLV
TASVSNHNQT LNYELLDFSM HQSHGQSQVY GQPSSLHESS QSSNGFYLQV TKDAQQGVRD
GGTLSIQTAV STSTSQAPPG PPPAAPNTQQ TQSEPPKTSD SKVALQQQRD APAVPVSGAQ
PSQGQYSTPA QGPTGGNAPP PVAPGAWPPG TQGAVPPGNP QAVPAEAPRP PSSAGSHQDY
VHPPSGSGQM YSSYYGNYGE YPDSRGQYPP GQYPPPPGDP RMQQYYQDAN YRGRGDPYYG
RYDGQNPGYR DPNYQYREPQ SERPNSRASQ YSDRPSSRQG YSEDYQRQNR SAYGEYYADY
PKHYDYRGYN YGQYDQRYRG YYDQSYWSYY NETYRNGYYN QPRKDVYDAH WLYYPGYDRS
FDDDNVRGRD AYGDDFDRHS VHSERSAHSV HSSTSHHSRQ SSFSSRSQQS QVYRSQPDLV
SAVYDTTQST LPVDYSYGQY PNQTDATQNY SQYMYPSEYT ADSTWIASEQ PPPRPATPEK
FTMPHRCARF GPGGHLIQVL PNLPSAGQPA LVEIHNMETM LQDTADQAEL RGFPGPLIKE
ETHKVDVIKF SQNKAMECSR DNNLLDRDSA RLIWDFIVLL CRQNGTVVGT DIADLLLKEH
RSVWLPGKSP NEANLIDFNN EPLARAEEEP GAGPLSLLSD TFMIVPENVG KETERFRELL
LFGRKKDALE AAMKGGLWGH ALLLASKMDN RTHARVMTRF ANSLPMNDPL QTMYQLMSGR
MPASATCCGE EKWGDWRPHL AMVLSNLTHN MDLDTRTITT MGDTLASKGL TDAAHFCYLM
AQVGLGVYTK KSTKLVLIGS NHSLAFNQFA TNEAIQRTEA YEYAQSLGSQ PCSLPNFQVF
KLIYACRLAE SGLSAQAFHY CEVIAKTVLM HASYYSPVLI SQIIQMSEKL RFYDPQLKER
PEQELFIEPE WLIRLKHLDG QIRTGVITYN RDRSTPAQFD CISESSDFEP QSPHEPYSMP
LEVDGQGPDN QLMSSLMPGP QPQAVQLMPP APSSILHEGA APAQLTPSSD VPQFYPVPPS
GPPCQIPMPG FPPQDPAGVA HPPFHPQHEQ AYPGAHQQFV PPPQEGQMSP HMLPSQVPHS
PVQMTHPPFQ MPQHMPPSPG HMVPMEQPLP PHPEMHPTHP ISSSPPRSSF TPQMDLYDHM
AIMGPRRSRT TSQSSMHLPS GRSSRRASES STHSGGRERS NSAVKQASPP PPSIPEQPRK
EEARKAKKDS PEKSKGWSFW PFGKRKNEAH LPDDKNPSIV WDENKNRWVD LNEPEEESKP
PPPPPTGFPK MPQMPGPGGP TAPPGAGSTV NMFSRKAGTR SRYVDVLNPS GTAKPSGVAP
APVDLFAPLA PMPMSANLFV PSSAPSNQQP LEGSEGGNQE QNSPSSGAAP QVFNPTLLPP
APEGPPVPDG SQSGESHPNQ GTAPAGGVTF YNPTQFSQTS ASSGGGQRSS RLGQRQYPVY
K
//
