ID A0A3P9N0U8_POERE Unreviewed; 1180 AA.
AC A0A3P9N0U8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Ski2 like RNA helicase {ECO:0000313|Ensembl:ENSPREP00000003206.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000003206.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000003206.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000003206.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 8081.ENSPREP00000003206; -.
DR Ensembl; ENSPRET00000003260.1; ENSPREP00000003206.1; ENSPREG00000002277.1.
DR GeneTree; ENSGT00940000158255; -.
DR OMA; CGSDITR; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000002277; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18027; DEXHc_SKIV2L; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 1.20.1500.20; -; 1.
DR Gene3D; 2.30.30.1160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 272..428
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 543..708
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 36..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1180 AA; 132222 MW; 6619CAEF8EB65460 CRC64;
XCVVLSADVP PVGPMDLPLS LLEMGRSGRF ELITHPLPDQ PLPPQSTLPH GLPPTSLGLE
REVEKRFLQD PSWLPIHDTD FAFQKVTERK VDVDSLLSCG PSPLHSGLSV VRDPTTGMLL
DFTEVLLENT GLSAKNSLSL QRQPGPPSES LRGSNTNYPF LPGGMEELTL DQIKTRSEQE
EEIDFEKDLL KIPPGLKAGM DFSDTGLVQD IQKIYKFAGK TDKSKPXXNX EEKKKWAIPV
DILSPCEDFY KRIPKPAFKW PFELDTFQKQ AVLRLEAHDS VFVAAHTSAG KTVVAEYAIA
LSQKHMTRTI YTSPIKALSN QKFRDFKNTF GDVGLLTGDV QLSPESSCLI MTTEILRSML
YNGSEVIRDL EWVIFDEVHY INDAERGVVW EEVLIMLPDH VSIILLSATV PNALEFSEWI
GRIKKRHIYV ISTMKRPVPL EHYLYTGNST KTQKEMFLLV DAAGNFLTKG YYTAVDTKKE
RTSKHAQSFG TKSTPQHTSA SQDRAVWLTL LHFLSQRQQT PVVAFTFSRT RCDENARSLD
SMDLTTSIEK AEIHSFFQKS VSRLRGGDRQ LPQILLMRDL LKRGIAVHHS GILPILKEVI
EMLFSRGLVK VLFATETFAM GVNMPARTVV FDSIRKHDGT GFRNLLPGEY IQMAGRAGRR
GLDATGTVII LCKAGVHDMA DLHAMMMGKP TILQSQFRLT YTMILNLLRV EALRVTDMMS
RSFSESHRDT QAHEKRISHL KQMLASLPPL ETEGQLSDIL PYYHIATEMQ NTREALQKAI
MESVNGLKAL SVGRVVIVNN KQHLNALGVI LQVSSDSMNR TFTTLIICEK GNEEVAGKAE
DSTSFQHLYN TALFIPEGPC SHTVQKLKLQ DISAITVKTL KVIPDRIIDN YNKRQQLRFR
ADPPGQAIST ATQELLRLAE ANPGGVATLD PVNDLQLKSV DVVEGSMRLR VLQDSLRDFN
CVHSPTFFAR IKERMSVQEE LDRLLFLVSD QSLMLLPEYH QRIKVLQSLQ YIDSSGAVQL
KGRVACQISS HELLLTELLF ENVLSPLAPE ESAALLSCLV FNQNTQTDIE RVLSVAQRIG
QLQRECGIAQ TAEEFVGQFK FGLTEVVYCW ARGMPFAEIA LLTDVQEGTV VRCIQRLDEV
LKEVRQAARI VGDSVLGSKM EKASLAVRRD IVFTASLYTH
//
