ID A0A3P9N3M9_POERE Unreviewed; 996 AA.
AC A0A3P9N3M9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Rho guanine nucleotide exchange factor 26 {ECO:0000313|Ensembl:ENSPREP00000004117.1};
GN Name=ARHGEF26 {ECO:0000313|Ensembl:ENSPREP00000004117.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000004117.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000004117.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000004117.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9N3M9; -.
DR Ensembl; ENSPRET00000004176.1; ENSPREP00000004117.1; ENSPREG00000002916.1.
DR GeneTree; ENSGT01030000234571; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000002916; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11938; SH3_ARHGEF16_26; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035797; ARHGEF16/ARHGEF26_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12845:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 563..748
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 780..907
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 915..975
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 112..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 996 AA; 111095 MW; 88B25A267239B441 CRC64;
MDLGNDVDLS NNNITPLWRR RTDLSEGSQD LNKLKPRPVS YHLNGVTTAD FPAGDDGRSF
TLSQPPQPLN ANTMVLKHVL HKPSEKKRIV RSISIGRLYN GRFSLSKFRA EDKSATLDNR
GSSRRNNQNG SVCSKNHHQD LQRSTTNPLD LDLEKDQISS GTNTPPPETP TDNCSSHVHS
PHTPNHCHYE LSSQSSASSS SSPGYGTLTP SHSSSSSIPS LLSLTSSDPP TPRSPSPADR
GNPLQSQTTS PASSYDTLYA SSSSSSFSTS PSLSPTASPS PTVVLSTNSP AALKMGTQQL
IPKGLASDVR QTKAPPAGTQ RLGLDHSKRA IKVLSMVEAG GYFSTGGGHT EEAEGETESP
GALRRALRST SYRRAVVTEV DKDVTLVELK MPVMEGLENP GSPTGSTNLS TLSPTSAEAP
KAASPRISKS SSPRMDKTKS NKKSKIPNRK KLMPQRTFDS EGNTCLFGSF FLMHSAVLMS
LYFEIKNWLL FFFVTTNISE EELYQNYQEK ALHNDSDEDA DSRGPKPDQG IVVQYRPIRT
SWSQLSVVKK NGLAEQLSQE ERKRQEAIFE MISSEHSYLH SLEILIRMFK NSSELSEVMT
KIEHHHLFSN ISDVCEASKK FFKELEDRHQ QSLVIDDISD IVCKHAESSF DPYIKYCSNE
VYQQRTLQRL VGAKNSAFKE VLTRLEGHPD CRNLPMSSFL ILPMQRVTRL PLLLDTICQK
TSKDSAHYET CKKALQAVSK VVRKCNEGAR TMERTEMMYT ISTQLQFKIK PFPLVSSSRW
MVKRGELTAF VEDSGIFAKR KSRHHVYFFL FNDVLIVTKK KGEDSHTVID YALRDQIQVG
SSQPEDVHLS PVKSPTSMLS SRQVGANHLF RLCFRSNHSS EKVAMILGTE LENERARWIS
ALGQNDNDDR RHDRTNVTQV EVIRTYTAKQ PDELSLQVAD VVLVSQHVDG WYEGERLRDG
EAGWFPAECG EEITCQATIE RNMQRMDRLQ GLETNV
//
