ID A0A3P9N747_POERE Unreviewed; 908 AA.
AC A0A3P9N747;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Rho GTPase-activating protein 44-like {ECO:0000313|Ensembl:ENSPREP00000005411.1};
GN Name=ARHGAP44 {ECO:0000313|Ensembl:ENSPREP00000005411.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000005411.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000005411.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000005411.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9N747; -.
DR Ensembl; ENSPRET00000005482.1; ENSPREP00000005411.1; ENSPREG00000003700.1.
DR GeneTree; ENSGT00940000157296; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000003700; Expressed in head.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF13; RHO GTPASE-ACTIVATING PROTEIN 44; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 14..253
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 259..449
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 160..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..663
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..743
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..888
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 99352 MW; A1FA63A2964EAB74 CRC64;
MKKQFNRMRQ LANQTVGRAE KTEVLSEDLL QVEKRLDLVK QVTHSTHKKL TACLQGQQGT
DTEKKSVKSP SKKLPLTILA QCMEEGAAVL GDDSLLGKML KLCGDTEDKL AQELLQFELQ
IERDVVEPLY VLAEVDIPNI QKQRKHLAKL VLDMDSARTR YQQSSKSSSH PSTMQPGAKS
ESLREEMEET ANRMEICRDQ LSADMYNFVA KEIDYANYFQ TLIETQAEYH RKSLEILHSV
LPQIKAHQEA WVEKPSFGKS LEEHLNISGR EIAFPIEACV TMLLECGMEE EGLFRVAPSA
SKLKKLKASL DCGVLDVQEY SSDPHAIAGA LKSYLRELPE PLMTTELYDE WIQASNIQDM
DKRLQALMAV CEKLPTDNLN NFRYLIKFLA KLSEYQDSNK MTPGNMAIVL GPNLLWTQTE
PNMTEMMTTV SLQIVGIIEP IIQHADWFFP GEIEFNLTGC YGSPIHTNHN SNYSSMPSPD
MDQSERKQQQ HDQNRRPLSV ATDNMMLEFY KKDGIRKIQS MGVRVMDTSW VSRKGSSTLT
RKTSSTPPGM QGPSSPADTL IPEQPGELAT SPSATPPLGE RVCSENVSLN RPDTSFAHPT
PGEDRPPPPY PSSSCHSVPH HFYPKPPPCA RPVAPGPESQ PPGSPPPPVR WSGFTPPAPP
PSSSSSSSSS SLDINSNPKP SCLHFPKYSP PGDLSQAPPL DTNASPLYVK TPLLLTRHDQ
SHSNLPSLPS SAPPPPPWAA CPCARERGPP RLTSSLKSKE LSPVIGHKGI QVASPTVPPS
CSPQSSSQSP HSTEHSPHAL RKGSKKLAPV PPKVPYAQSG GMSDQSTGQV PPSSPGQTPL
GPTHSLSSPP SLSGTLTKSR PAPKPRQRPS LPPPQPPPAP PPLAPVPQPL EQGLLDGLSP
GESMSTAV
//
