ID A0A3P9N8G9_POERE Unreviewed; 1393 AA.
AC A0A3P9N8G9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=ATP binding cassette subfamily A member 3 {ECO:0000313|Ensembl:ENSPREP00000005861.1};
GN Name=ABCA3 {ECO:0000313|Ensembl:ENSPREP00000005861.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000005861.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000005861.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000005861.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 8081.ENSPREP00000005861; -.
DR Ensembl; ENSPRET00000005942.1; ENSPREP00000005861.1; ENSPREG00000004013.1.
DR GeneTree; ENSGT00940000155289; -.
DR OMA; WKNWIVL; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000004013; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF250; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 930..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 973..999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1011..1035
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1047..1065
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1135..1156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 445..678
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1393 AA; 155494 MW; 3DFC673E7D5DE702 CRC64;
VTYLSHFTTV LFKHYKRQIL VTLVEILLPL LFSGILIVLR QKVPFQDYPN ATIYESFPVN
ILPSHIPRDL QLGYVPSNSS VVRQVAEDVX ASLSLHSVRG FETEEQFERH VRTDPQSHQI
LAAVIFEHPF THDDEPLPLQ VSYHLRFTFT PRNAPPREKS ELSPNSDLDW HTLSLFPLFQ
LPGPREQHDK DGGTPGYYRE GFLAVQHAVD KAIMRSXNST GANRLLKQTR VVLSRFPYPS
FIYDVFILAI QNQLPLLLVL SFTYTSLNIV RAVVQEKXPL SQGEANVAAA AGGFIYFLSY
LPYLFLWPRY DLLSHAQKVS ACLISNVAMA MGAQLIGMFE GKGTGIQWSN LLDSVTVDDD
FSMAQVLCLL LFDSVLYGLV AWYMEAVFPG EYGVPLPSYF FLLPSYWCSS PRMAIVNEKE
EEEDAEKAMK GEFIEEEPAG VVSGIKIKHL TKEFKVGNKT RQAVRDLTLN MFEGQITVVL
GHNGAGKTTT LSMLTGLFPP SGGRAYINGY DICQDMALIR RSLGLCPQHD VLFDNLTVRE
HLLFYAQLKG FPKEQISDEV DRIICILNLE DKRHSRSKTL SGGMKRKLSI GIALIGDSKV
VMLDEPTSGM DPSARRATWD LLQGEKRGRT ILLTTHFMDE ADLLGDRIAI MAGGELQCCG
SPLFLKNKYG AGYHMVIVKD SLCNVSEITR LVHMYVPNAT MESSAGAELS YILPKESTSR
FELLFAELEM NKEELGIASY GASVTTMEEV FLRLGHKIFL IFIPHGVTFF HSFLVARTLP
NHQDAPMLRL ALSHYGPTRV PVALQPGAGS LSSSLAEMYT SQLLEQLGEL RNITDFTNYV
LTNAKAEGGV FNERCVVGAA FLGRSSRYSE ATAYFNNQGY HTPATALMMV DNALFKLLAG
PNASILTGNY PMPRNLSETA RSQLTDKTGF AIAINLMYGM ASLSSTFALL LVTESAIKSK
HVQQVSGVYL SNFWFSALLW DLVNFLLPCL LMLVVFQAFG VEAFVADHHL IDVLLILLLY
GWAIVPLMYL LSFFFSTAAT AYTRLTIFNM ISGTATFLTV TIMTIPELNL VHLSHLLDKV
FLIFPNYCLG MSFSQFYQNY EFIKFCTSSE ISEVICKVLN ITYQPNYFSM SEPGVGRFLV
SLSVQGVVFN ALLFVIELQC VRTXCRLFTS LGRKRKQVTL LDDAAFLPED RDVAEERKRV
LDCQPVVESM VGSPLILHEL SKVYSSGENL LAVDRLSLAV GKGECFGLLG FNGAGKTTTF
KMLTGDESVT SGDAYIDGYS ILRDIKKVQQ RIGYCPQFDA VLDHMTGRET LSMYARLRGI
PEKYVAGCVE NVLRSLSTPA EITVCHILKK GNLHHCKCVL YCTMELNLSN LYVSLSFFNK
IMPSLQMGAN LRV
//
