ID   A0A3P9N8V3_POERE        Unreviewed;       551 AA.
AC   A0A3P9N8V3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000005963.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000005963.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000005963.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSPRET00000006045.1; ENSPREP00000005963.1; ENSPREG00000004138.1.
DR   GeneTree; ENSGT01100000263487; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000004138; Expressed in caudal fin.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT   DOMAIN          41..205
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|Pfam:PF05729"
FT   DOMAIN          286..345
FT                   /note="NOD2 winged helix"
FT                   /evidence="ECO:0000259|Pfam:PF17779"
FT   DOMAIN          347..474
FT                   /note="NACHT LRR and PYD"
FT                   /evidence="ECO:0000259|Pfam:PF17776"
SQ   SEQUENCE   551 AA;  63400 MW;  8C5060E491CE7007 CRC64;
     GRNTDCFYSL ILKFKTTNEE TSIKYCDIFK PTNSNQNIKA VLTVGVAGIG KTFASMKYVL
     DWSKATENFS FIFPLPFREL NLRADKXHSL EDLIHQFFPA MRTSEITDYD KYKILIVLDG
     FDECRLDLEF XXXNKXXDVX TPTXMNVLLS NLILGNLLPK AQIWITSRPA ASNNIPPEKV
     DRMTEVRGFN DEQKEKYFMK RFSDEKVAEK IWSYVQKSRI LYMMCHIPVF CFITSKVLED
     FVERKQDVGL PKTLTDMYTH FLLLQHQSTS ETSGTETFCD KTNDETILSL GKLAFKGLEE
     KNLLFTEEDL TSCGTDVTKA AVFSGLLTQI KRANHDLYQQ KMFCFVHKSI QEFMAALHVF
     HSFTNKGENV FTESTSATSD LTASEFYKKA VDKAFESKHG DWDMFLRFLV GLSLESNQDL
     LQDLMDKSEK HKDASKEAAE YIKKKIRENN SDTEKNLNLF YCLNELNDDT LVQEIKNYLN
     SEEKPFEKFT ASQWSALTFV LLTSDEKLEV FDLKKYLKSE KVLLGMIKPS SNLTELDLSH
     NDLLDAGVFQ S
//