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Database: UniProt
Entry: A0A3P9N8Z2_POERE
LinkDB: A0A3P9N8Z2_POERE
Original site: A0A3P9N8Z2_POERE 
ID   A0A3P9N8Z2_POERE        Unreviewed;       748 AA.
AC   A0A3P9N8Z2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Bromodomain-containing protein 2 {ECO:0000256|ARBA:ARBA00040998};
GN   Name=BRD2 {ECO:0000313|Ensembl:ENSPREP00000006036.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000006036.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000006036.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000006036.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBUNIT: Homodimer. Interacts with E2F1 and with histone H4 acetylated
CC       at 'Lys-13'. {ECO:0000256|ARBA:ARBA00038820}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A3P9N8Z2; -.
DR   Ensembl; ENSPRET00000006120.1; ENSPREP00000006036.1; ENSPREG00000004149.1.
DR   GeneTree; ENSGT00940000153385; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000004149; Expressed in head and 1 other cell type or tissue.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   CDD; cd05497; Bromo_Brdt_I_like; 1.
DR   CDD; cd05498; Bromo_Brdt_II_like; 1.
DR   Gene3D; 1.20.1270.220; -; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR   InterPro; IPR043508; Bromo_Brdt_I.
DR   InterPro; IPR043509; Bromo_Brdt_II.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR018359; Bromodomain_CS.
DR   InterPro; IPR027353; NET_dom.
DR   InterPro; IPR038336; NET_sf.
DR   PANTHER; PTHR22880:SF240; BROMODOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR   Pfam; PF17035; BET; 1.
DR   Pfam; PF00439; Bromodomain; 2.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 2.
DR   SUPFAM; SSF47370; Bromodomain; 2.
DR   PROSITE; PS00633; BROMODOMAIN_1; 2.
DR   PROSITE; PS50014; BROMODOMAIN_2; 2.
DR   PROSITE; PS51525; NET; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW   ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          83..155
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          320..392
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          579..661
FT                   /note="NET"
FT                   /evidence="ECO:0000259|PROSITE:PS51525"
FT   REGION          43..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          413..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..583
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          657..748
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..61
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..236
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..448
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        496..519
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        520..536
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..564
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        657..688
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        706..748
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   748 AA;  83777 MW;  C597F168CFEAFC6C CRC64;
     MFLSDLSSLV GLSSGMLDQH CSSGKRIRKP SLLYEDFESP SLPHTMTQAT PAPPQPPVKD
     PSRPGRMTNQ LQYLQKTLIK CLWRHHFAWP FHEPVDAYRL NLPDYYKIIK QPMDMGTIKK
     RLENNFYQSA GECIQDFNTM FTNCYIYNKP TDDIVLMAQS LEKIFLQKVA QMPQEEVELP
     PPAPRSKNSR GRGRKSNPSR AQQVPAVSQS AYSPSSSDTG DSMLASSPQT VLTKSLPPAN
     IMGLPPTQPT TKKKGVKRKA DTTTPSTLGF TVGMVGSGRP IKPPKKDLPD SVQPQLSKKG
     KLSPQLRYCS GLLKEMLSKK HAAYAWPFYT PVDTTALGLH DYHDIIKCPM DLSTIKRKMD
     CREYRDAQQF ASDVRLMFSN CYKYNPPDHD VVAMARKLQD VFEFRFAKMP DEPPMEHTAM
     SVIGHPTSSS SSSSSSSSSS SSTSESEPSS DSEESESSLS SDSEEERAHR LAELQDQLRA
     VHEQLAALSQ GPIVKPKKKK EKKEKKEKKK KKKVEKRSRA GRSRAGSEEW KMPGKMLKSK
     SARAGVSQAK RAQTKKSNKN NKLKPFYPTL APSTLPHYDS EEEEEIVPMT YDEKRQLSLD
     INKLPGEKLG RVVHIIQSRE PSLRDTNPEE IEIDFETLKP STLKELERYV MTCLRKKPRK
     PYEVKNKGSM SKEELTLEKR RELERRLQDV SGQLNSVKKP TKPKGELTLC SSNAHAQPSR
     LSGSSSSSDS SSSSSSSSSS DTSDSDST
//
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