ID A0A3P9NBB7_POERE Unreviewed; 666 AA.
AC A0A3P9NBB7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Dynein, cytoplasmic 1, heavy chain 1 {ECO:0008006|Google:ProtNLM};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000006855.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000006855.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000006855.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR AlphaFoldDB; A0A3P9NBB7; -.
DR STRING; 8081.ENSPREP00000006855; -.
DR Ensembl; ENSPRET00000006944.1; ENSPREP00000006855.1; ENSPREG00000004704.1.
DR GeneTree; ENSGT00940000156103; -.
DR OMA; HEACHEL; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000004704; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 1..49
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 141..472
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 501..662
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT COILED 145..193
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 342..439
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 666 AA; 76679 MW; 579D456863939E8A CRC64;
MNGLSVYQIK VHRKYTGEDF DEDLRTVLRR SGCKNEKIAF IMDESNVLDS GKMDLEKPNY
KVPDYMPIVY DKLPQPPSHR EAIVNGCVFV HQTLHQANNR LAKRGGHTMA ITPRHYLDFI
NQYANLFNEK RSELEEQQMH LNVGLRKIKE TVDQVEELRR DLRIKSQELE AKNAAANDKL
KKMVKDQQEA EKKKVMSQEI QEAVYKQQEV IKDKQLSVKQ DLDQVEPAVI EAQNAVKSIK
KQHLVEVRSM ANPPAAVKLA LESICLLLGE STTDWKQIRS IIMRENFIPT IVNFEAEEIS
DSIREKMKKN YLSNPSYNYD QVNRASLACG PMVKWAIAQL NYADMLKRVE PLRNELQKLE
DDAKDNKTKA EEVEQMIRDL EASIARYKEE YAVLISEAQA IKADLAAVEA KVNRSTALLK
SLSAERERWE KTSETFKNQM STIAGDCLLS AAFITYAGYF EQQMRQNLFT TWSHHLQQAN
IQFRTDIART EYLSNADERL RWQANSLPAD DLCTENAIML KRFNRYPLII DPSGQATEFI
MNEYKDRKIT RTSFLDDAFR KNLESALRFG NPLLVQDVES YDPILNPVLN REVRRTGGRV
LITLGDQDID LSPSFVIFLS TRDPTVEFPP DLCSRVTFVN FTVTRSSLQS QCLNEVLKAE
RSLLLM
//
