ID A0A3P9NC89_POERE Unreviewed; 518 AA.
AC A0A3P9NC89;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA polymerase epsilon subunit {ECO:0000256|PIRNR:PIRNR000799};
DE AltName: Full=DNA polymerase II subunit 2 {ECO:0000256|PIRNR:PIRNR000799};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000007185.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000007185.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000007185.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Participates in DNA repair and in chromosomal DNA
CC replication. {ECO:0000256|PIRNR:PIRNR000799}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR000799}.
CC -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC {ECO:0000256|ARBA:ARBA00009560, ECO:0000256|PIRNR:PIRNR000799}.
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DR AlphaFoldDB; A0A3P9NC89; -.
DR Ensembl; ENSPRET00000007276.1; ENSPREP00000007185.1; ENSPREG00000004895.1.
DR GeneTree; ENSGT00390000012435; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000004895; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.60.21.60; -; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR024639; DNA_pol_e_bsu_N.
DR InterPro; IPR016266; POLE2.
DR PANTHER; PTHR12708:SF0; DNA POLYMERASE EPSILON SUBUNIT 2; 1.
DR PANTHER; PTHR12708; DNA POLYMERASE EPSILON SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF12213; Dpoe2NT; 1.
DR PIRSF; PIRSF000799; DNA_pol_eps_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR000799};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR000799};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR000799};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 5..60
FT /note="DNA polymerase epsilon subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12213"
FT DOMAIN 278..478
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
SQ SEQUENCE 518 AA; 58112 MW; FAA46CBD051043F8 CRC64;
MDVSRKIKTK VSAGFKMRGL ILRPEASRYL VEVLESVDSS ELDDVVEKVL DAVEKQPCKS
FNRVKMFEFC LKVNIYNVFN IIGAFDVPRY IYSVERKKFV PISMTSHPAP GLCGLARDKA
ELFRERYTIL QQRTHRHELF TPPAIGAAVV EGQNKFQLRT IEALLGSTAK LGEVIVLGMI
TQLKEGKFYL EDPSGTVQLD MSKFHNGLYT ESCFVLAEGW YEDSVFHVNG FGFPPTESSS
ATRAYYGNIN FFGGPSSTSV KASSKLKQLE EENEDAMFVI VSDVWLDSVE VMEKLNIMFS
GYAALPPTCF ILCGNFSSAP YGKTQIKSLR ESLKTLADVI CSYPSIHSSS RFVFVPGPDD
PGPGTVLPRP PLADHITQDF QQRVPGSVFT TNPCRIQYCS QEIIVMREDL VNKMCRNCVR
LPNSNLDIPN HFVKTVLSQG HLTPLPLYVS PVFWAYDYSL RVYPVPDVIV FADKYDPFSI
SSTDCLCLNP GSFPRSGFTF KVYYPSNRTV EDSKLQGL
//
