ID A0A3P9NDB4_POERE Unreviewed; 832 AA.
AC A0A3P9NDB4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=CSC1-like protein 2 {ECO:0000313|Ensembl:ENSPREP00000007556.1};
GN Name=TMEM63B {ECO:0000313|Ensembl:ENSPREP00000007556.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000007556.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000007556.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000007556.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR AlphaFoldDB; A0A3P9NDB4; -.
DR Ensembl; ENSPRET00000007648.1; ENSPREP00000007556.1; ENSPREG00000005091.1.
DR GeneTree; ENSGT00940000157084; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000005091; Expressed in head and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR PANTHER; PTHR13018:SF38; CSC1-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 54..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 118..222
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 238..420
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 431..686
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 750..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 94540 MW; 96174CA4068BFE9A CRC64;
MLSALIVTME SVGSSPACSE QKNCTADDES KDYCYSARIR STVLQGLPFG GVPTVLALDF
MCFLVLLFVF SILRKVAWDY GRLALVTDAD SVASAMHSET PDRYERLTSV SSSVDFDQRD
NGFCSWLTAI FRIKDEEIRE KCGEDAVHYL SFQRHIIGLL VVVGVLSVGI VLPVNFSGDL
LENNAYSFGR TTIANLKSET KLLWLHTTFA FMYLLLTVYS MRRHTSKMHY KEDDLVKRTL
FINGISKYAD ESQIKQHFEQ AYDNCVVLEA RICYNVAKLM ALSAERKKTE RSKKFFTDLM
AKEHVPTMIN PKPCGHLCCC AIAGCEEEEA VSYYTKREAK LKEEYRKEKE KVHTKPLGMA
FVTFQNEAMT AIILKDFNAC QVQGCRCRQE PCSSQFSEVL HVHNWSVTYA PDPQNVRWEH
LSLGGISWWI RCFIINCILF ILLFFLTTPA IIISTMDKFN VTKPVEYLNN PIITQFFPTL
LLWAFSALLP TIVYYSAFFE AHWTRSGENR TTMHKCYTFL IFMVLLLPSL GLSSLDVFFR
WLFDKKFLDD AKVRFECVFL PDNGAFFVNY VIASAFIGNA MDLLRIPGLL MYMIRLCLAR
SAADRRNVKR HQAYEFQFGA AYAWMMNVFT VVMAYSITCP IIVPFGLMYM LLKHLVDRYN
MYYAYLPSKL DKKIHSAAVT QVVAAPILCL FWLLFFSTVR TSFDTPTSMF TLVVLVVTIV
VCLSHVCFGH FKYLSAHNYK IDTKESEVDA VKNGRPARSS SSPSSKSQVA PQQQMYIAQV
LQDPNSDEPG GASSEEDRGS SQDEEMLNGG NGINEADFQS GEDSLIANEV HQ
//
