ID A0A3P9NE86_POERE Unreviewed; 1904 AA.
AC A0A3P9NE86;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Otoferlin {ECO:0000313|Ensembl:ENSPREP00000007859.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000007859.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000007859.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000007859.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 8081.ENSPREP00000007859; -.
DR Ensembl; ENSPRET00000007951.1; ENSPREP00000007859.1; ENSPREG00000005299.1.
DR GeneTree; ENSGT00940000155086; -.
DR OMA; WANIYGA; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000005299; Expressed in head.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF32; OTOFERLIN; 1.
DR Pfam; PF00168; C2; 6.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00239; C2; 6.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1869..1891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..98
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 235..356
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 395..530
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 942..1067
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1114..1240
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1382..1500
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1621..1772
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 650..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..681
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1904 AA; 216573 MW; E813A1120431B061 CRC64;
MSIVVHLKTV AHLRGKGDRI AKVTFRGLPL YSRVAENCGE EAHFNETFRW PIASRLDHNE
MLEIQVYNYS KVFTNRLVGT FCMVLQKVAE EGHLELTDTL IDDNNMSIKT SVTIDIRYQP
MDGTGGMWSD GEFLDVPDDR DGMFAFETDS LLSGQSHGSG TSPGRSLQGA GRGVFSAMKL
GKAKSLKDDH KRGDDPAILE MEDLDKKAMR LAGMLEPDTI SLASVTAVTT NVSNKRSKPD
IKMEPSSGRP VDYQISITVI EARQLIGLNM DPVVCVEVGD DKKYTSMKES TNCPYYNEYF
VFDFHVPPDV MFDKIIKLSV IHSKNLLRSG TLVGTFKMDV GTVYSQPEHQ FYHKWAILSD
PDDITAGCKG YVKCDIAVVG KGDNIKTPHK ANETDEDDIE GNLLLPEGIP AERQWARFYV
KIHRAEGLPK MNTSIMANVK KAFIGENRDL VDPYVQVQFS GQKGKTSVQK SSYEPIWNEQ
VIFTELFPPL CKRIKVQIRD SDKVNDVAIG THFIDLRKIS NDGDKGFLPT LGPAWVNMYG
STRQYTLMDE HQDLNDGLGE GVSFRARLLI SVAVEILDTT SPETICSTDV QVEPVSNISE
SATGKMEEFF LFGSFLEATM IDRKIGDKPI SFEITIGNYG NHIDGVSKSS VKKKKKEGEN
QEEENELIQN SSEDEADEDA DLTSVSSTPP MKPFITDRNY FHLPYFEKKP CVYIKSWWQD
QRRRLYNSNM MDKIADKLEE GLNDVQEVIK TEKAFPERRL RGVLEELSIG CSRYVTLANK
DVNLAGRTKL DRERLKSCMR EMDSMGQQAK QIRTQVKKNT VKEKLKLAQN FLQRLRFLAD
EPQHSIPDVF IWMMSNNKRI AYARIPSKDI LYSVVDEETG KDCGKVKAVF LKLPGKKGFG
PAGWTVQAKL ELYLWLGLNK SRKDFLHGLP NGFEEIRATK TGHGLPPVTL VYDMKQVFQL
RAHMYQARSL FAADSSGLSD PFARVFFSSQ SQVTEVLNET LCPTWDQLLV FDDVELFGEA
TELRDDPPII VVEFYDQDTV GKAEFIGRTF AKPIIKMRDE PYGPPRFPPQ LEYYQIYRGN
SIAGELLAAF ELLQVGQGGR ADLPPLEGPT DSERGPILPV PLGIRPVLSR YRIEVLFWGL
RDLKRINLAQ VDRPRVDIEC AGRGVQSALI QNYKKNPNFS TLVKWFEVDL PENELLHPPL
NIRVVDCRAF GRYILVGSHA VSTLRHFIYS PPDKSCNNWA TAGTFSLKDL YDKEKKKKKK
KKKGGVEEEE ETDERVLDWW SKYFASIETL KENLRSQEAA QAEAEEREDL EIAAEAVYNK
ELESEYGNFE DWLHTFNLYR GKAGDDDEHA LDDDRIVGRY KGSLCMYKVP LSQEITREAG
YDPNMGMFQS IPHNDPIHVL VRVYVVRATD LHPADINGKA DPYVVIKLGK SEVKDKENYI
SKQLNPVFGK SFDIEATFPM ESMLTVSVYD WDLVGTDDLI GETKIDLENR FYSKFRATCG
IASNYSMHGY NIWRDPMKPS QILAKLCKEG KIDGPHYGPG GKVKVANRIF TGPTEIEDEN
GLKKQTEEHL ALSVLNHWEE IPRVGCKLVP EHVETRPLLN PDKPGIEQGR LEMWVDMFPM
DMPAPGPAID ISPRKPKRYE LRVIIWNTDE VILEDDDYFT GEKSSDIFVR GWLKGQQEDK
QDTDVHYHSL TGEGNFNWRF VFPFDYLVAE EKIVISKKES MFSWDETEYK IPPRLTMQVW
DADHFSADDF LGAIELDLNR FPRGAKTAKQ CNLDMIRNEQ ELPTISIFKQ KRVKGWWPFV
ARDENDEMEL TGKVEAELHL VTAEEAEKSP VGLGRNEPDP LEKPNRPDTS LMWFLGPLKS
LRYFIWHNYR WLILKALGLI LLLLMLGLFL YSIPGYLVKK ILGA
//
