ID A0A3P9NEU5_POERE Unreviewed; 102 AA.
AC A0A3P9NEU5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=SOSS complex subunit C {ECO:0000256|ARBA:ARBA00014540, ECO:0000256|RuleBase:RU369016};
DE Short=SOSS-C {ECO:0000256|RuleBase:RU369016};
DE Short=SSB-interacting protein 1 {ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Sensor of single-strand DNA complex subunit C {ECO:0000256|ARBA:ARBA00030383, ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Sensor of ssDNA subunit C {ECO:0000256|ARBA:ARBA00033066, ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Single-stranded DNA-binding protein-interacting protein 1 {ECO:0000256|ARBA:ARBA00031967, ECO:0000256|RuleBase:RU369016};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000008052.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000008052.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000008052.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC functions downstream of the MRN complex to promote DNA repair and G2/M
CC checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC lesions and influences diverse endpoints in the cellular DNA damage
CC response including cell-cycle checkpoint activation, recombinational
CC repair and maintenance of genomic stability. Required for efficient
CC homologous recombination-dependent repair of double-strand breaks
CC (DSBs). {ECO:0000256|RuleBase:RU369016}.
CC -!- SUBUNIT: Component of the SOSS complex.
CC {ECO:0000256|RuleBase:RU369016}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369016}.
CC -!- SIMILARITY: Belongs to the SOSS-C family.
CC {ECO:0000256|ARBA:ARBA00007829, ECO:0000256|RuleBase:RU369016}.
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DR RefSeq; XP_008422093.1; XM_008423871.2.
DR AlphaFoldDB; A0A3P9NEU5; -.
DR STRING; 8081.ENSPREP00000008052; -.
DR Ensembl; ENSPRET00000008146.1; ENSPREP00000008052.1; ENSPREG00000005504.1.
DR GeneID; 103473554; -.
DR KEGG; pret:103473554; -.
DR CTD; 58493; -.
DR GeneTree; ENSGT00390000006366; -.
DR OMA; ENQSMNV; -.
DR OrthoDB; 2913067at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000005504; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0070876; C:SOSS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:UniProtKB-UniRule.
DR InterPro; IPR031821; SOSSC.
DR PANTHER; PTHR31526; SOSS COMPLEX SUBUNIT C; 1.
DR PANTHER; PTHR31526:SF2; SOSS COMPLEX SUBUNIT C; 1.
DR Pfam; PF15925; SOSSC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU369016};
KW DNA repair {ECO:0000256|RuleBase:RU369016};
KW Nucleus {ECO:0000256|RuleBase:RU369016};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
SQ SEQUENCE 102 AA; 11278 MW; 4210BD4D31469F68 CRC64;
MAANPPGQAI PSKARVAILA ELEKEKRRLR ENQSMNVPGA SIPLSRPNMK EFRDSAELQH
IATQQRAALQ HAHTHSSGFF ITQDSSFGNL ILPVLPRLEP QS
//
