ID A0A3P9NEW8_POERE Unreviewed; 1508 AA.
AC A0A3P9NEW8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Bromodomain containing 4 {ECO:0000313|Ensembl:ENSPREP00000008028.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000008028.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000008028.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000008028.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_017161665.1; XM_017306176.1.
DR Ensembl; ENSPRET00000008121.1; ENSPREP00000008028.1; ENSPREG00000005463.1.
DR GeneID; 103468755; -.
DR CTD; 23476; -.
DR GeneTree; ENSGT00940000162790; -.
DR OrthoDB; 152619at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000005463; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR031354; BRD4_CDT.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF143; BROMODOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF17105; BRD4_CDT; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 116..188
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 433..505
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 693..775
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 35..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..59
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..626
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..923
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1070
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1213..1228
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1339..1361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1362..1421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1423..1451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1508 AA; 167459 MW; F92E4E043BCC2F74 CRC64;
MVQLTYQHVD SSEECNGISG TLSVESVPGP RLNWCSASTT TPAPTLAPAP VPGPEPTPYP
VRMGDGLDTA QMSGSSQGQA QQTGNPPAPE FFSPNRPKRQ TNQLQYLLKV VVKSLWKHQY
AWPFHSPVDA IKLNLPDYYS IIKIPMDMGT IKKRLENSYY WNAQECIQDF NTMFTNCYIY
NKPGDDIVLM AEALEKAFLQ KVAEMPQEEI EIPVMTGKGR GRGRREGGLN LKPGSIIDSS
STTPQTRGLS NLPVAPQSLG PMQAPSVLPP HPSIQTLPSL VPQTLPSLAP QLGAPYTMVQ
PDCVPQVPIM TSVPLPTQTS LPPVPIQNTA PMLQSPITMT KQKKSQKRKA DTTTPTANDQ
LSESSPAESK SGKTLPRRES SRPPKLLKKE APDSQHHIGM VTGLSGPSGG LSPKPQDQLG
YCAGLVRDML SKKHAAYAWP FYKPVDVDAL GLHDYHDIIK HPMDLTTIKA KLETKQYRDP
QEFAADVRLM FSNCYKYNPP DHEVVSMARK LQDVFEMRFA KMPDEPETKP VVSAQTPTLH
HPAPVKPQPH LAHVHTSSDS SSDSSSESES STDDSEEERA QRLAELQEQL KAVHEQLAAL
SQPQPSKPKR KEKEKKEKKK DKHKKKGSIP SHVDEIQDPP PIPQLPKKTK TTNNNKDVVT
KKKPSKKEVL KNSHPPSLQH VPNLEDDLGT TGPPVPGEKC KPMTYEEKRQ LSLDINKLPG
DKLGRVVHII QSREPSLKNS NPDEIEIDFE TLKPSTLREL ERYVSSCLKK KKRIPPEKTV
ESVAPSKKTI SSSESSGSSS DSEAEGSGMI KLPKKKSQSV KEGKKMHPHV QTGSAQTGFQ
SQAVVSQASS QMKQQQHQPS PAGFMPPPPV AALESSHLLE SYEPLPPFNQ PIMHLPHHTG
NSSPPSPHIN AHSAGSVSPE THPFLNQHPV LPSPALHSSM PQQPSRPSHK AAPLHPKPPQ
QQQQQQPAPP QQQQQPALQQ QPQLQPQSAP PPQHQLPPQI LHTHQPLHQR PMSPPTLTPQ
GLLSSQPPQM LLEDDEEPGS TTPMNQVQLF LHQFQPARQP QQSMQSHQVP VRQQLQLQQL
GQTSLLQTAT MQAQSQLSAQ TSLPPPQLSV PSQAQPTASH QAPPPQITLH QXRHLQNTQH
QQQQVQQHQL NYQQGPGLAG QSQASQHNIS MPSNKAQQII QQQQEQPSPR PSKPDPYNTG
HIRDNPSPLM MHSPQIPQFP PVSHPSPPHN MQPKKQRAPG SQVAVKEDKL PPSPVMRGEH
FNSAMRAEHH KHPEIKPSQT GQSQQSLKSV DSSRPIIRSS EPSGPPPSLQ EKEKFKQEPK
TPVAPKKVQD VKFKNMGSWA SLAQKSTSTT QSAVKSSSDS FEQFRRAARE KEEREKALKA
QAEAEKDRLR KEQDKQRGRD EEDVIEPPPR RVHEESRGRL EPQHIQAPSQ QQPQPQQVQV
QQESQPAAVQ QSPQPTTPPQ PSTQNSLDQQ RELARRREQE RRRREVMAAT IDMNFQSDLM
AIFEENLF
//
