ID A0A3P9NGI8_POERE Unreviewed; 579 AA.
AC A0A3P9NGI8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Beta,beta-carotene 9',10'-oxygenase-like {ECO:0000313|Ensembl:ENSPREP00000008642.1};
GN Name=BCO2 {ECO:0000313|Ensembl:ENSPREP00000008642.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000008642.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000008642.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000008642.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC {ECO:0000256|ARBA:ARBA00006787, ECO:0000256|RuleBase:RU003799}.
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DR AlphaFoldDB; A0A3P9NGI8; -.
DR STRING; 8081.ENSPREP00000008642; -.
DR Ensembl; ENSPRET00000008743.1; ENSPREP00000008642.1; ENSPREG00000005912.1.
DR GeneTree; ENSGT00950000182913; -.
DR OMA; CKNFFAR; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR InterPro; IPR004294; Carotenoid_Oase.
DR PANTHER; PTHR10543:SF107; B,B-CAROTENE-9',10'-DIOXYGENASE-RELATED; 1.
DR PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR Pfam; PF03055; RPE65; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR604294-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT BINDING 220
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 284
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 355
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 572
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ SEQUENCE 579 AA; 65962 MW; CC71358C035A77F7 CRC64;
MRVQRFPKLV YFLCPSRVES RELAVMSTNT ESQTHSLPSR ERCPQASGLE SVAPLLHSGE
ETPDPIPTTT MGIIPAWING SFLRNGPGKF EFGEDRYNHW FDGMALMHRF HICEGSVTYS
SRFLRSDSYN LNSERNRIVV SEFGTVAMPD PCKNFFARFL SRFQIPQPTD NANVNFVKYK
GDYYVSTETN FMRRVNPQTL ETKEKVDWSQ YVAVNSATAH PHYDREGATY NMGNSYGRDG
FFYTIIRIPP AEEAAAKEDS ADLSGAEVIC SIPAAESRKP SYYHSFVMSE NYIVFVEQPI
KLNVLKFMLY KIMGESFQKI LSWEPQYGTV FHLVDRHTGQ ESKVKYRTAP MFTLHQINAY
EDNGFLVMDM CCGDDGAVIG DFTLENLRQE SGDDLDKFYN SLCRNLPRRY VLPLNVDEQT
PLDQNLVMLP NCKATAKRTN SGEVYMTHEE LHNEELLQYG GLEFPQINYD TYNGRPYRYF
YACGFGHVFA DSLLKMDVHT KELKVWRYPG LFPSEPVFVA SPDAAEEDDG VVLSVIITPR
KEKSTFLLVL DAKTFTELGR AEVPVNIPCG THGVFNETG
//
