ID A0A3P9NGV6_POERE Unreviewed; 1276 AA.
AC A0A3P9NGV6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE Short=PARP {ECO:0000256|RuleBase:RU362114};
DE EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000008816.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000008816.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000008816.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
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DR AlphaFoldDB; A0A3P9NGV6; -.
DR Ensembl; ENSPRET00000008922.1; ENSPREP00000008816.1; ENSPREG00000005920.1.
DR GeneTree; ENSGT00940000156161; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000005920; Expressed in head and 1 other cell type or tissue.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd09524; SAM_tankyrase1_2; 1.
DR CDD; cd01438; tankyrase_like; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 6.20.320.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 5.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR24178:SF45; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 17.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 15.
DR PROSITE; PS50088; ANK_REPEAT; 15.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU362114};
KW NAD {ECO:0000256|RuleBase:RU362114};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|RuleBase:RU362114}.
FT REPEAT 164..196
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 197..229
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 230..262
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 317..349
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 350..382
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 383..415
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 470..505
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 506..538
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 539..571
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 632..664
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 665..697
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 698..730
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 785..817
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 818..850
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 851..883
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 981..1040
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1063..1266
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 137473 MW; ED2EDF782926A54A CRC64;
MATPRRSSQQ QQQQQQLSTL LSSPPRSTSI PVSPPESPSA PAEDASRFSR GAEMENVADG
EVAPTSPNTT SPALALTPSS SNSNSSSSSS SSTTSSPTTT EGSETSPGST PDSGGANPRS
SSTISGDANG AFRELFEACR NGDVSRVKKL VDVVNVNAKD MAGRKSTPLH FAAGFGRKDV
VDHLLQTGAN VHARDDGGLI PLHNACSFGH SEVVSLLLCQ GADPNARDNW NYTPLHEAAI
KGKIDVCIVL LQHGADPNIR NTDGKSALDL AEPSAKAVLT GEYKKDELLE AARSGNEEKL
MALLTPLNVN CHASDGRKST PLHLAAGYNR VRIVQLLLQH GADVHAKDKG GLVPLHNACS
YGHYEVTELL LKHGACVNAM DLWQFTPLHE AASKNRVEVC SLLLSHGADP TLLNCHSKSS
VDMAPTPELK ERLTYEFKGH SLLQAAREAD MTKAKKTLAL EIINFKHPHT HETALHCAVA
SPHPKRKQVT ELLLRKGANV NEKNKDFMTP LHVAAERAHN DIMEVLQKHG AKVNALDTLG
QTALHRAALA GHLQTCRLLL GYGADATLVS LQGFTAAQMG NEAVQQILNE NVPVRNSDVD
YRLLEAAKAG DLDTVKSLCT AQNVNCRDLE GRHSTPLHFA AGYNRVSVVE YLLHHGADVH
AKDKGGLVPL HNACSYGHYE VAELLVRHGA SVNVADLWKF SPLHEAAAKG KYEICKLLLK
HGADPTKKNR DGNTPLDLVK DGDTDIQDLL RGDAALLDAA KKGCLARVQK LCSPDNINCR
DTQGRNSTPL HLAAGYNNLE VAEYLLEHGA DVNAQDKGGL IPLHNAASYG HVDIAALLIK
YNTCVNATDK WAFTPLHEAA QKGRTQLCAL LLAHGADPTM KNQEGQTPLD LATADDIRAL
LIDAMPPDAL PSCLKPQATV VSAAGGVVIS PSPSPSCLSA ASSIDNLTAP LGDIATAGAT
GVADGASGSD RKEGESLLDM TINQFLKSLG LEHLRDIFQR EQISLDVLAD MGHEELKEIG
INAYGHRHKL IKGIERLLGG QQGGNPYLTF HCSSQGTVLI DLAPDDKEFQ SVEEELQSTI
REHRDGGNAG GVFMPSLFFF FVVNKKLRER YAHRQKEIAD ENHNHHNERM LFHGSPFINA
IIHKGFDERH AYIGGMFGAG IYFAENSSKS NQYVYGIGGG TGCPTHKDRS CYVCHRQMLF
CRVTLGKSFL QFSAMKMAHA PPGHHSVIGR PSVNGLAYAE YVIYRGEQAY PEYLITYQIM
KPESLAAPAA TAEQKS
//
