ID A0A3P9NHQ5_POERE Unreviewed; 1411 AA.
AC A0A3P9NHQ5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Multiple EGF like domains 6 {ECO:0000313|Ensembl:ENSPREP00000009077.1};
GN Name=MEGF6 {ECO:0000313|Ensembl:ENSPREP00000009077.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000009077.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000009077.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000009077.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSPRET00000009186.1; ENSPREP00000009077.1; ENSPREG00000006025.1.
DR GeneTree; ENSGT00940000156971; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000006025; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 7.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR InterPro; IPR000716; Thyroglobulin_1.
DR PANTHER; PTHR24043:SF8; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 5.
DR Pfam; PF00053; Laminin_EGF; 6.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 28.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00180; EGF_Lam; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 16.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1411
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018048121"
FT DOMAIN 56..96
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 308..348
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 444..479
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 834..869
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 877..912
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 920..955
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 968..998
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1093..1128
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1265..1300
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1343..1411
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DISULFID 469..478
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 859..868
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 902..911
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 945..954
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 988..997
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1118..1127
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1290..1299
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1367..1374
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 1411 AA; 150843 MW; 92B618FF6EAFBAA6 CRC64;
VMALAAGWWI FFLVLIEATA SLAANYPYVY YRRICHRPHC YYGYHGYNTG YLPAADIDEC
QVHNGGCQHR CINTRGSYYC ECHPGSRLHV DGRTCLTVFS CAVRNGGCEH YCLQQSASHF
RCRCKPNYVV AEDGKHCKLQ NPCADQNGGC MHECRVDGGK PFCDCKRGYL LAEDGKTCED
IDECKTEETN CAHGCRNTLG SYACVCNTAY ELGSDGKQCY RIEMEIVNSC ESNNGGCSHH
CQHSTSGPVC TCNHGYRLND DLKTCVDVDE CGEQSSCCEQ DCTNYPGGYE CYCSAGHRLN
ADGCSCDDVD ECLAANGACD HTCQNTAGSF QCFCRRGFQL DQDRRSCICA VELSLIHPQL
TLLRDYDQPL ERYDNYEDDD GELRAESSLA EKFVCLDDTF GSDCSLTCDD CTNGGICNIW
KNGCDCPDGW TGIICNQTCP AGHFGKNCSF SCKCKNGASC DSVSGSCRCP PGVTGDLCQD
GCPKGFYGKQ CNKKCNCANN GRCHRTYGAC LCEAGLYGRF CHLPCPKWTF GAGCSQECQC
DQKKTKHCHR HHGTCICKPG YHGSTCCKTG TFGLGCEQKC ACPPGASCDH VTGACQRKCP
AGRHGEKCEQ ECPEGMFGPG CIQPCNCTGA PCDKETGQCH CQAGTHGEHC ENFCDAGHWG
AGCAETCDCR NGDGSCDAVT GRCSCEAGFT GPSCQQSMLL QYLLNFFTCF ICCHIAASNL
CVLVRRIKEQ CPFHSCLLVF GLPSECPAGL FGLSCRRLCQ CENEAQCDHV SGACTCQVGW
TGSFCEKPCP QGFYGLDCQE KCFCQNGGSC DHVSGVCSCP AGWIGTFSCL AGFYGPGCNR
TCGCRNGGIC HPAGGQCSCM PGWTGPNCTE ECPAGLYGAD CQQVCLCQNG ATCNKTDGKC
SCPAGWTGTA CELECTAGRF GADCQQRCEC ENGGVCDSQA GRCSCSAGWV GERCEKACEA
GLYGAGCTER CRCAHGVSCH HMTGECRCPP GWRGKLCDKA CLPGTFGEGC MQRCSCAQET
SCHHISGECG CPPGFTGNGC EQTCIPGLFG PNCNRVCQCS ETNQLCHPVS GSCYCAPGFH
GSKCDQSCEE GRYGPDCQKE CRCENGGRCV PSTGSCECPA GFIGPSCNIT CPVGRYGVDC
NRVAACGDGA QNDPVTGRCV CIPGRRGEDC GQSCPPGWFG GDCTQRCNCS NGGLCDSATG
NCTCGLGWTG ERCDIECPVG RFGANCQLKC SCQNNGSCDK VTGTCRCGSG YYGHLCEHVC
PPGFHGPLCQ LQCDCMNGAT CHPVLGHCIC PPGHHGARCH RVCELGRYGQ GCVGVCDCED
GSPCDPVTGR CICPSGKTGA RCDIDCRGDR YGPDCAETCE CKNGAQCDRH NGRCLCVHSW
IGLSCQEGTP LTNTHALGRQ QASQNQRMYP C
//
