ID A0A3P9NIB1_POERE Unreviewed; 702 AA.
AC A0A3P9NIB1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=RAP1 GTPase activating protein 2 {ECO:0000313|Ensembl:ENSPREP00000009279.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000009279.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000009279.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000009279.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9NIB1; -.
DR Ensembl; ENSPRET00000009391.1; ENSPREP00000009279.1; ENSPREG00000006302.1.
DR GeneTree; ENSGT00940000165230; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000006302; Expressed in head and 1 other cell type or tissue.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 223..439
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 77038 MW; 6E692308B334D861 CRC64;
MFSPASKGSA GDSRKQELLN ISNVPLGECP PSPPRTAPPS MKSADFFDML EKMQDDYIPY
PRIEDVLEKG GPYPQVILPQ FGGYWIEDAE APAGTPSSSE SSFCEEEDGD EGMSPGGARS
YRLECNSTAR AYRKHFLGKE HMNYYCTGSS IGNLIMSLKH EEAQGQEFLR IMLRSRTKTV
HDRISLAGIS QLPSVPQIAK LLCDDAPGLR FSPVLYPRGS QLIVAYDEHE VNNTFKFGVI
YQKFGQTSEE ELFGNNEETP AFKEFLSILG DNIELQDFKG FRGGLDVSHG QTGSESVYTV
FRHREIMFHV STKLPFTEGD VQQLQRKRHI GNDIVAAVFQ EESTPFVPDM IASNFLHAYV
LVQVENPCTD HTTYKVSVTA REDVPPFGPP LPNPAVFKKG PEFREFLLTK LINAENACYK
SDKFAKLEGR TRAALLDNLH DELHRQSQAV LGLGQMGEED KLENGGHGGL LESFKRAMRV
RSHSMETVVG SHRHRSPGVA GGVPASLSGG GLPQSTSECT KSTFTPPVLS AKSPLKSPVK
RRSGLFPRLH SSTDAPSDKH TRSDHKPAEI CPHSQEVRSE TSSNPSSPEI CPNKERPFMK
HKECSSGSSC RPNISRSSSS TSSFSSTTGE TEALEELETV SHPSITSTSA FSPSLSIDSQ
GSSTPVIMCR SPTDGKGKTS PRSSLKFRFD KMSHSSTAVS LK
//
