ID   A0A3P9NNG9_POERE        Unreviewed;       591 AA.
AC   A0A3P9NNG9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=heparosan-N-sulfate-glucuronate 5-epimerase {ECO:0000256|ARBA:ARBA00012087};
DE            EC=5.1.3.17 {ECO:0000256|ARBA:ARBA00012087};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000011111.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000011111.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000011111.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n);
CC         Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557,
CC         ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00000434};
CC   -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004841}.
CC   -!- SIMILARITY: Belongs to the D-glucuronyl C5-epimerase family.
CC       {ECO:0000256|ARBA:ARBA00005584}.
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DR   RefSeq; XP_008402874.1; XM_008404652.2.
DR   RefSeq; XP_008402875.1; XM_008404653.2.
DR   RefSeq; XP_008402876.1; XM_008404654.2.
DR   RefSeq; XP_008402877.1; XM_008404655.2.
DR   RefSeq; XP_008402878.1; XM_008404656.2.
DR   RefSeq; XP_008402879.1; XM_008404657.2.
DR   AlphaFoldDB; A0A3P9NNG9; -.
DR   STRING; 8081.ENSPREP00000011111; -.
DR   Ensembl; ENSPRET00000011238.1; ENSPREP00000011111.1; ENSPREG00000007567.1.
DR   GeneID; 103462118; -.
DR   KEGG; pret:103462118; -.
DR   CTD; 100007670; -.
DR   GeneTree; ENSGT00390000006043; -.
DR   OMA; RGVFMYF; -.
DR   OrthoDB; 5392022at2759; -.
DR   UniPathway; UPA00862; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000007567; Expressed in head and 1 other cell type or tissue.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0047464; F:heparosan-N-sulfate-glucuronate 5-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:InterPro.
DR   GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR010598; C5-epim_C.
DR   InterPro; IPR039721; C5-epimerase.
DR   PANTHER; PTHR13174; D-GLUCURONYL C5-EPIMERASE; 1.
DR   PANTHER; PTHR13174:SF3; D-GLUCURONYL C5-EPIMERASE; 1.
DR   Pfam; PF06662; C5-epim_C; 1.
DR   Pfam; PF21174; Glce_b_sandwich; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          390..580
FT                   /note="D-glucuronyl C5-epimerase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06662"
SQ   SEQUENCE   591 AA;  66280 MW;  DFA6E432DD3A9AE1 CRC64;
     MRCLAARVNY KTLIVICALF TLITVLLWNR CSSDISIRFL PRAAFVVPSA KISSSQQQPP
     QPPEPPPVVG VVGGIKYEEI DCLINDESTI KGRREGGEIY LPFSWVEKYF EVYGKVVQYD
     GYDRFEFQHS YSKVYAQREP YHPEGVFMSF EGYNVEVRDR VKCISGVEGV PLSTQWGPQG
     YFYAIQIAQY GLSHYSKNLT ERAPHIEVYD TAEEKDSRVS TASWNVPKGC SLSRVHDKTR
     STSVRSFSAA DSSEGVSLQL GNSKDFILSL DLKFASNGSV SVVLETTEKG PPFTIHYVTN
     TQLIAFKERD VTYGIGPRSS WSTLTRDLLT DLRKGVGLSN TKAVKATKIM PRRVVRLVLH
     GRGFVDNVTI STTAHMAAFF AASDWLVRNQ DERGGWPIMV TRKLGEGFRP LEPGWYSAMA
     QGQAMSTLVR AYLLTKTQAY LNAALKAVGP YKVPSAQHGV KAVFMNKYDW YEEYPTTPSS
     FVLNGFIYSL LGLYDVADTA GEILGREAGQ LFSRGMESLK AMLPLFDTGS GSIYDLRHFM
     LGTAPNLARW DYHTTHINQL QLLASIDNAP IFRDVVKRWK NYLKGIRAKH N
//