ID A0A3P9NP55_POERE Unreviewed; 673 AA.
AC A0A3P9NP55;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Membrane frizzled-related protein {ECO:0000313|Ensembl:ENSPREP00000011355.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000011355.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000011355.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000011355.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR AlphaFoldDB; A0A3P9NP55; -.
DR STRING; 8081.ENSPREP00000011355; -.
DR Ensembl; ENSPRET00000011482.1; ENSPREP00000011355.1; ENSPREG00000007745.1.
DR GeneTree; ENSGT00940000154525; -.
DR OMA; WMCDLWR; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000007745; Expressed in head.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR CDD; cd07066; CRD_FZ; 1.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF36; MEMBRANE FRIZZLED-RELATED PROTEIN; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00063; FRI; 1.
DR SMART; SM00192; LDLa; 2.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 153..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 235..346
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 394..507
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 555..673
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT REGION 193..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 353..365
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 360..378
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 372..387
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 514..526
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 521..539
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 533..548
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 673 AA; 73875 MW; BB9721AE218E9F8E CRC64;
MDRQQRNSMC RRIEDWKFLQ SKRRLTLWAK CMMVRKLWKM SLKNSNTEKA LSLRCSSRFI
PKYAGPLERT ADRNQNFPLR LKMSDLSQVS VYSDSSDIYK NVFCNPAFEL EGEQEERVDG
FRTSSSTPEP IKPPAASFVE MCSMRLRGRG GGWGVVVVSA AALLLLTAIG LALALILTQL
KSQAVDNHLT TTSTGLQSTG HDVPHTPTAA PLNRSHMDST AIPQPAVTPQ SETSCGGVLT
DSGGSFSSPD HPGSYPSNSH CVWVIRVAPP HLVQIRVSYL AVEGPSPCLF DWLEVQQQVE
QTSVFTRFCG NVAPPTINTN SSTVWVTFHS DSSIAGAGFA AQYRAVLPAQ KSCSREEFMC
DGGRCLLPVS VCDGHPNCND QTDEANCSQK HKECGGQKSG PYGYLASPNH PRPYPHQQLC
VWHLSVDEGH VITLSFRNFS LETQDVCEFD YVEAHDSSSI GAGRVLGRFC GTTFPPDLTS
SGPHMTVVFV ADEGVADSGF NATYQAVSVL NRTCGPNQVA CSTGECLQQQ WLCDGWSDCS
DGADEQGCAN STYPPFTSSC EIIEVEMCRG LSYNFTSFPN IWLSIADQRE AATLLRQYRV
LMELACFEPL RKLVCGMFLP QCSPQGGVLQ PCRSVCSSAE QQCSQALDLF SFSWPFNCHL
LPDSQDPVEC SQP
//
