ID A0A3P9NQK2_POERE Unreviewed; 416 AA.
AC A0A3P9NQK2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000011844.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000011844.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000011844.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR RefSeq; XP_008414153.1; XM_008415931.2.
DR AlphaFoldDB; A0A3P9NQK2; -.
DR Ensembl; ENSPRET00000011975.1; ENSPREP00000011844.1; ENSPREG00000008057.1.
DR GeneID; 103468689; -.
DR KEGG; pret:103468689; -.
DR CTD; 9951; -.
DR GeneTree; ENSGT00940000161466; -.
DR OMA; GARDAWP; -.
DR OrthoDB; 10019at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000008057; Expressed in head.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF11; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 4; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transferase {ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 152..387
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT REGION 113..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 161
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 161..165
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 242
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 250
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 367..371
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 350..362
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 416 AA; 47830 MW; E6F58C1484DB43F2 CRC64;
MAFWSSTSVF TSKVPRKILF MFTLSLSVTY LFYSLMSCYN SLQFPLQENY VFQGRLVTED
TTFVTLREKL YSASPVFTEF TQGERTTAAP TVGEHDEAEP RTVEWIRTQA SPTKSAAAFR
PTAPERERQE ISTTDSELRV NCTSDYGEKK LPQAIIIGVK KGGTRALLEA LRVHPDVRAV
GNEPHFFDRN YEKGLDWYRD LMPSTLEGQI TMEKTPSYFV TNHAPKRIHS MAKDIKLIIV
VRNPVTRAIS DYTQTLSKKP EIPTFEVLAF KNRTLGLIDA SWSALRIGIY ALHLESWMQY
FPLSQMHFVS GERLIVDPAG EMAKVQDFLG LKRIVTDKHF YFNKTKGFPC LKKPEDSSTP
RCLGKSKGRT HPKIDPDVIR RLHKFYKPFN MMFYQMTGQN FEWELEEDSV SRSSQD
//
