ID A0A3P9NSQ0_POERE Unreviewed; 1360 AA.
AC A0A3P9NSQ0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA repair protein REV1 {ECO:0000256|ARBA:ARBA00020399};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000012488.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000012488.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000012488.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008432715.1; XM_008434493.2.
DR STRING; 8081.ENSPREP00000012488; -.
DR Ensembl; ENSPRET00000012620.1; ENSPREP00000012488.1; ENSPREG00000008480.1.
DR GeneID; 103479827; -.
DR KEGG; pret:103479827; -.
DR CTD; 51455; -.
DR GeneTree; ENSGT00940000156374; -.
DR OMA; IKNGMWM; -.
DR OrthoDB; 169741at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000008480; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR GO; GO:0042276; P:error-prone translesion synthesis; IEA:InterPro.
DR CDD; cd17719; BRCT_Rev1; 1.
DR CDD; cd01701; PolY_Rev1; 1.
DR CDD; cd12145; Rev1_C; 1.
DR CDD; cd19318; Rev1_UBM2; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 6.10.250.1630; -; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR Gene3D; 1.20.58.1280; DNA repair protein Rev1, C-terminal domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR InterPro; IPR012112; REV1.
DR InterPro; IPR031991; Rev1_C.
DR InterPro; IPR038401; Rev1_C_sf.
DR InterPro; IPR047346; Rev1_UBM1/2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45990; DNA REPAIR PROTEIN REV1; 1.
DR PANTHER; PTHR45990:SF1; DNA REPAIR PROTEIN REV1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00817; IMS; 2.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF21704; POLH-Rev1_HhH; 1.
DR Pfam; PF16727; REV1_C; 1.
DR Pfam; PF14377; UBM; 2.
DR PIRSF; PIRSF036573; REV1; 2.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 50..137
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 562..802
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1360 AA; 149120 MW; 8AB973A4DC214275 CRC64;
MSRDGWMRKR ANGSDDNGWG ERGGYMAAKV TKLDEQFKLN ATREKQKEGT GSSIFSGVSI
YVNGYTDPSA DELRRLMMLH GGQFHIYYSR SKTTHIIANN LPNCKIQELR GEKVIRPEWI
TDSIKDGRLL PCFKYQLYAK QKNTLFPAVI LRHTSEMSEP SHCPLQLSKH QKPLLPPHNT
EPSVPRSGGS SNNPFPVPGC SEAEPQSVRR SSKASLDCHH PSHLKSSQLV SGSLHTSRSL
HKYPLPNKGH AKLPHKSPGS AHVNDEDLKI NGVLQASPDT SSHSKMMEMQ ERGDPCPVGA
SAAVGEAPLT NGHAHLFNGA LKPEGSSPVA DPRSSDGDAS TCRAKSSTEK PQSSSVQSHA
KPDPYEFPPS PPKQSDSLPI RLEQSSTQDG GLCDPKPPSS SAHEALRANE PQTPLKCLRP
PAHVEPISEQ TSQPPPSCSL SSVRLNGSRH KAFLTDAPLP NAARVAAKPD PPTEAPSAST
SSDQLLEQTG GLISEFYSHS RLHQISTWRI AFSEYVNELH SKRKTEGSPS YPGKERLRKS
MAQRSTHGQA CASSAISVKS CIFHVDMDCF FVSVGIRHRP ELKGKPVAVT SNRGLGKVPI
RPGANHQVEL QYYQMRHTHP QPEKADDDLP VTPSQDTPDS HGNGMDPDAT ALSMAEIASC
SYEARQAGVR NGMFFGKAKQ LCPSLQSVPY DFDAYKEVAL NMYEILASYT HDIEALSCDE
ALIDASHLLA EVGVTPDGLA EAIRADIQGK TGCCASVGMG SNILLARLAT RKAKPNGQYF
LRSEEVDDFI RDLPVTSLPG VGHIMAKKLA VMGVKSCGDL QQVSLSQLQK KFGPRTGQTL
FRFCRGLDDR PVRFEKERKS VSAEMNYNIR FATEDEAECF LTNLSMEVQR RLKEAGLRGR
RVTLKVMVRK VGAPLEPAKY GGHGICDNLA KTVMLAQSTD SGQLIASAVI KLLHAMKLQV
QDLRGVGIQV QQLEGNQPQA HDCRGTRTRS IKDMLLGKGS NARTTNKAGT PQKQTFSVAA
LSPPHPLTPA EPVPGTSKET PVCRAAQKHS WTRLNLSIEV PSPSQVDRSV LEALPAELRE
QVEQSWTKRD ERPNHCRSPD LQLSSPHPAP YAPPAGTLVL QFPNQPDSPG IVLELPNFSQ
VDPDVFAALP KELQDELKSA YSRANNVQPQ VKMAEQKNPL LQLKPPAAGT GVGRLKRRYK
RKNGVSPVKK GTSPLKRRHS TNSPAKRVPP IKPQEPANVP KTEMNPSTSE QDVMVSVTKS
LPRPVPTLAG ACDLTDIKTL LREWVTTITE PMEEDILQVV KYCTDLIEDK DLEKLDLIIR
YMKRVMQQSV ESVWSMAFDF ILDNIQVVVH QAYGSILKIT
//
