ID A0A3P9NWX9_POERE Unreviewed; 501 AA.
AC A0A3P9NWX9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000014065.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000014065.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000014065.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the tweety family.
CC {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361114}.
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DR AlphaFoldDB; A0A3P9NWX9; -.
DR Ensembl; ENSPRET00000014210.1; ENSPREP00000014065.1; ENSPREG00000009514.1.
DR GeneTree; ENSGT00950000183060; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000009514; Expressed in head.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd07912; Tweety_N; 1.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424:SF6; PROTEIN TWEETY HOMOLOG 2; 1.
DR PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR Pfam; PF04906; Tweety; 2.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU361114};
KW Chloride channel {ECO:0000256|RuleBase:RU361114};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361114};
KW Ion transport {ECO:0000256|RuleBase:RU361114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361114};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT TRANSMEM 45..73
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 212..234
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 360..382
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
SQ SEQUENCE 501 AA; 56182 MW; 5D9F9DA9218443D0 CRC64;
MSLTRVDYIA PWWTYWLHNF PHINLRFQPT DKSFQPEDEN YQQSLIFLGC VAAAGLGLNL
LCLAVYLSFL CCCRKDEEEE TKKPNSCCVT WSAVTAGLIT CISVGVGFYG NSETNDGVYQ
LTYSLYNANH TLGGVDSLVS TMGNMRTGLH QHLARLDEIF ATRGDYVQTL QFMQQMADNV
IKQLLGLPDW DEATVDLAAV ADQTANIEYY RWLTYLLLLI LDLVICLLAC LGLAKQSRWL
LTTDFCVSPD KYVMGQTKGL ITADIVHYYI YCNQTLSNPF QQPLTIFQRS LTTMQIQIQG
LLQFAVPLFP TAERDLLGIQ HLLNSSEASL HQLTALLDCR GLNKDYLDAM VGVCYDGVEG
VLYLCLFSIL AACAFTVMLC AIPRALRERD YDDIDEEDPF NPRARRIGSQ NPNHANMHSF
CSYSSSMGSQ NSLQPPAPAV SNPPMSEYMN QTALFGGNPR YENVPLIGRG SPPPSYSPTM
RATYLSMTEE QRRHFGSDFQ A
//
