ID A0A3P9NXG9_POERE Unreviewed; 701 AA.
AC A0A3P9NXG9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Phosphoinositide-3-kinase regulatory subunit 2 {ECO:0000313|Ensembl:ENSPREP00000014262.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000014262.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000014262.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000014262.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR AlphaFoldDB; A0A3P9NXG9; -.
DR STRING; 8081.ENSPREP00000014262; -.
DR Ensembl; ENSPRET00000014407.1; ENSPREP00000014262.1; ENSPREG00000009679.1.
DR GeneTree; ENSGT00940000157050; -.
DR OMA; QSDMGFL; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000009679; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd12926; iSH2_PIK3R2; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..80
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 108..276
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 309..404
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 598..693
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 84..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 416..450
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 488..536
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 701 AA; 80540 MW; 9737627A3DFA6AED CRC64;
MATDGFQYRV LYTFTKDQEE DLDLQPGDLL TVSKASLMSV QSFEDGFEEH PEHLGWLLGY
NERTKQRGDF PGTFVEFVGP IKMAHPSSQP RSQRPLPATP IPEPSHTVPV PDLSQQFTPP
ETAPPALVRL IQAIEHRGLD CKILYRTAST SDSSVYTLST EGDAAQSDMG FLSESVLRYL
RDLPSPVIPA CVYPQLQIAA MQQLLHQQFL DGAVAGSHDR EVLQAQASNG LDTHTLGRIF
GPLLIRTSPS AQGYSWEEDF PILVVERLLV ERTAQQDFPP PVLPAKPTKS KITPSDMTDT
SSLLNDAEWY WGDISREEVN EKLRDTPDGT FLVRDASSKL EGEYTLTLRK GGNNKLIKIY
HQEGRYGFSE PLTFQSVVEL INHYHHESLA QYNAKLDTKL LYPISKFQQL VKENSIEEVG
EQLKVYHEQY QEKSREYDSL YEEYTRTSQE LQMKRTAIEA FNETIKIFEE QFETQEKYSR
ESLERFQREG NEKEIQKIQS NSERLKSRVK EIHDSKRKLE QDLKEQVSDN REIDKKMNSL
KPDLMQLRKI RDQYLIWLTQ KGTRQKKINE WLGIKIDADD SYSLEEDDSS PHHDDCTWYV
GDIRRSQAEE MLRDKCDGTF LIRESQSQKG SYACSVVVDG DTKHCVIYKT RTGYGFAEPY
NLYSSLQELI LHYKNVSLAQ HNDHLNVNLA YPVLARSQNL K
//
