ID   A0A3P9NXL6_POERE        Unreviewed;       870 AA.
AC   A0A3P9NXL6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Semaphorin 6B {ECO:0000313|Ensembl:ENSPREP00000014326.1};
GN   Name=SEMA6B {ECO:0000313|Ensembl:ENSPREP00000014326.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000014326.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000014326.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000014326.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   RefSeq; XP_008405302.1; XM_008407080.2.
DR   RefSeq; XP_017159909.1; XM_017304420.1.
DR   AlphaFoldDB; A0A3P9NXL6; -.
DR   STRING; 8081.ENSPREP00000014326; -.
DR   Ensembl; ENSPRET00000014471.1; ENSPREP00000014326.1; ENSPREG00000009721.1.
DR   GeneID; 103463613; -.
DR   KEGG; pret:103463613; -.
DR   CTD; 100148883; -.
DR   GeneTree; ENSGT00940000159170; -.
DR   OMA; PTPHVDY; -.
DR   OrthoDB; 5399685at2759; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; SEMAPHORIN; 1.
DR   PANTHER; PTHR11036:SF10; SEMAPHORIN-6B; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..870
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018099524"
FT   DOMAIN          27..512
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
FT   REGION          617..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          786..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        637..655
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   870 AA;  97108 MW;  48E04C84CFA275EF CRC64;
     MAAGISHSLF LMCWILRTAS LAFPEEPGPL NFIPSEVVRR YPAFLGRPHQ TWLRQEPLHI
     QRIIQVNRTL YIGARDDLFR VELDNSAGDE MFYSKKRTWE SNKNDIRICR MKGKHEDECR
     NFIKVLLSRQ GGLFLCGTNA FNPLCANYTG DTLEMIGDPV NGMARCPYDP KHANVALFAE
     GNLFTATVTD FLAIDAVIYR SLGDSPALRT IKHDSKWFRE PYFVSAVEWG PHIYFFFREI
     AMEFNYLEKV VVSRVARVCK RDQGGSQRVL EKQWTSFLKA RLNCSIPGDS HFYFNLLHST
     SPVIRMHGRD IILGVFSTPA NSIPGSAVCA FDMEQLAAVF DGRFKEQKSP ESIWTPVPDE
     LIPKPRPGGC AVQGSKFNSS NSFPDEMLNF VKTHPLMDEA VPSLGQRPWI VRTMVRYQLN
     KIVVDTEAGP YRNRTVLFLG SSRGTILKFL IMPNQDNTVT SSNIFLEELE GFNPDKCAED
     SMQARQLLSL TLDRASHTLL LAFPSCVVRV PVARCQLYSR CMKNCIASRD PYCGWTRGST
     CSFLRPGTRL PFEQDVEHGN VAHLGDCDGI LFQESFIEEP DGLVSVNLLV VSAVSAFSTG
     AILSGLTVCW IMSHRHRSSR GSGANGARRK NDKEQTMLGQ GRSGSVMSVT RTSGGERRRS
     QPDNLFVMPN GWPKGEIDPG LLPTPEQTPL QQKRVMRLPD ADWDQSQTFL TSVGNPCPSN
     AVIYLSSKFL HGGGGGGGLV RIEDPGEVVL PTHSDRQRYL ILATQRGEHG GSRPTGSLRN
     SAGEYIYPAT PQDSPDRRRV VSAPTPHVDY GEPRWSHEAL NYNSNNGMPY YAQRQGLIRP
     DMHGPRGLGE LAEFSHLLGK NMGEHAPSGQ
//