ID A0A3P9NZY2_POERE Unreviewed; 512 AA.
AC A0A3P9NZY2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Integrator complex subunit 14 {ECO:0000256|ARBA:ARBA00016816};
DE AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000256|ARBA:ARBA00029992};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000015121.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000015121.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000015121.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC in their 3'-box-dependent processing. {ECO:0000256|ARBA:ARBA00003473}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the INTS14 family.
CC {ECO:0000256|ARBA:ARBA00007451}.
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DR RefSeq; XP_008410446.1; XM_008412224.1.
DR AlphaFoldDB; A0A3P9NZY2; -.
DR STRING; 8081.ENSPREP00000015121; -.
DR Ensembl; ENSPRET00000015277.1; ENSPREP00000015121.1; ENSPREG00000010197.1.
DR GeneID; 103466553; -.
DR KEGG; pret:103466553; -.
DR CTD; 81556; -.
DR GeneTree; ENSGT00390000009486; -.
DR OMA; QSSVVWI; -.
DR OrthoDB; 3673014at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000010197; Expressed in head and 1 other cell type or tissue.
DR GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR039841; INTS14.
DR InterPro; IPR045814; IntS14_b-barrel.
DR InterPro; IPR046471; IntS14_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR Pfam; PF19435; IntS14_b-barrel; 1.
DR Pfam; PF20504; IntS14_C; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 3..117
FT /note="VWFA"
FT /evidence="ECO:0000259|Pfam:PF13519"
FT DOMAIN 209..356
FT /note="Integrator complex subunit 14 beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF19435"
FT DOMAIN 404..511
FT /note="Integrator complex subunit 14 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20504"
SQ SEQUENCE 512 AA; 56507 MW; B9DA2903BFDD7B39 CRC64;
MPTVVLMDVS LSMTRPVSLD GIEEFQRKNL AVHGLNMLFE HMASNYRLEF TALMAFSSLW
ELLVPFTRDY NALQEALSNL EDYDKTCLEL ALQGVSSVVQ QEWGNGCPCQ VVLVTDGSLG
IGKGSLRHSL QTLKHRGDDK KFPLPYPFPT KMFILCIANA EELQMTDAME NLEELLHLSG
GDGQIFTVDG PLCMKSVQAM FGMLIDRAYS PFHAVLHCGN LSSDVQVFPR PEPVVVDEEV
EPIPRAVSTD LEIVGFIEIA DISSPPVISR HLVLPIAVSK EVDEVGTGAT DELEEEPSAS
QMAGKSPNFC VLLHGSLKVE GMVALVQLGP EWFGMLYSQA DSKKKSNLMM SLFEPGSDPL
PWLGKISHLG PVSEAAENPY GEDDSKSPFP VQPQVKRSYA QNVTVWIKAS GLQTDVQKIL
RNARKLPDKT QTFYKELNRL RKAALAFGFW ELLKGVAELL ERECTMLPDS AHPDAAFQLS
HAAHQLKLAS SGDSQYAAFD HNIVPMHTDF SS
//
