ID   A0A3P9P023_POERE        Unreviewed;       987 AA.
AC   A0A3P9P023;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Exportin-1 {ECO:0000313|Ensembl:ENSPREP00000015159.1};
GN   Name=XPO1 {ECO:0000313|Ensembl:ENSPREP00000015159.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000015159.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000015159.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000015159.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the exportin family.
CC       {ECO:0000256|ARBA:ARBA00009466}.
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DR   AlphaFoldDB; A0A3P9P023; -.
DR   Ensembl; ENSPRET00000015315.1; ENSPREP00000015159.1; ENSPREG00000010135.1.
DR   GeneTree; ENSGT00940000153408; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000010135; Expressed in caudal fin and 1 other cell type or tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR041123; CRM1_repeat.
DR   InterPro; IPR041235; Exp1_repeat_2.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045065; XPO1/5.
DR   InterPro; IPR014877; XPO1_C_dom.
DR   InterPro; IPR040485; XPO1_repeat_3.
DR   PANTHER; PTHR11223; EXPORTIN 1/5; 1.
DR   PANTHER; PTHR11223:SF15; EXPORTIN-1; 1.
DR   Pfam; PF08767; CRM1_C; 1.
DR   Pfam; PF18777; CRM1_repeat; 1.
DR   Pfam; PF18784; CRM1_repeat_2; 1.
DR   Pfam; PF18787; CRM1_repeat_3; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM01102; CRM1_C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          625..943
FT                   /note="Exportin-1 C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01102"
SQ   SEQUENCE   987 AA;  113069 MW;  6BEAA2BA75A7765B CRC64;
     MPEFCSSGKP SAGRPASIKK YVVGLIIKTS SDASSVEKEK VYIGKLNMIL VQILKQEWPK
     HWPTFISDIV GASRTSESLC QNNMVILKLL SEEVFDFSSG QMTQVKAKHL KDSMCNEFSQ
     IFQLCQFVME NSQNAPLVHA TLETLLRFLN WIPLGYIFET KLISTLVYKF LNVPMFRNVT
     LKCLTEIAGV SVSQYEEQFV TLFTLTMCQL KQMLPLNTNI RLAYANGKDD EQNFIQNLSL
     FLCTFLKEHG QLIEKRLNLR ETLMEALHYM LLVSEVEETE IFKICLEYWN HLAAELYRES
     PFSTSTSPLL SGNQHFDVPP RRQLYLPVLS KVRLLMVSRM AKPEEVLVVE NDQGEVVREF
     MKDTDSINLY KNMRETLVYL THLDYADTER IMTEKLHNQV NGSEWSWKNL NTLCWAIGSI
     SGAMHEEDEK RFLVTVIKDL LGLCEQKRGK DNKAIIASNI MYIVGQYPRF LRAHWKFLKT
     VVNKLFEFMH ETHDGVQDMA CDTFIKIAQK CRRHFIQVQV GEVMPFIDEI LNNINTIICD
     LQPQQVHTFY EAVGYMIGAQ TDQAVQEHLI EKYMLLPNQV WDSIIQQATK NVDILKDPET
     VKQLGSILKT NVRACKAVGH PFVIQLGRIY LDMLNVYKCL SENISAAIQT NGEMVTKQPL
     IRSMRTVKRE TLKLISGWVS RSNDPQMVGE NFVPPLLDAV LIDYQRNVPA AREPEVLSTM
     ATIVNKLGGH ITSEIPQIFD AVFECTLNMI NKNFEEYPEH RTHFFYLLQA VNSHCFPAFL
     AIPPAQFKLV LDSIIWAFKH TMRNVADTGL QILYTMLQNV AQEEAAAQSF YQTYFCDILQ
     HIFSVVTDTS HTAGLTMHAS ILAYMFNLVE EGKITVALNP GSPTNNQVFI QEYVANLLKT
     AFPHLQDAQV KVFVTGLFSL NQDIPAFKEH LRDFLVQIKE FAGEDTSDLF LEEREASLRQ
     AQEEKHKIQM SVPGILNPHE IPEEMCD
//