ID A0A3P9P036_POERE Unreviewed; 843 AA.
AC A0A3P9P036;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=CLCN5 {ECO:0000313|Ensembl:ENSPREP00000015174.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000015174.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000015174.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000015174.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR RefSeq; XP_008433563.1; XM_008435341.2.
DR AlphaFoldDB; A0A3P9P036; -.
DR STRING; 8081.ENSPREP00000015174; -.
DR Ensembl; ENSPRET00000015330.1; ENSPREP00000015174.1; ENSPREG00000010232.1.
DR GeneID; 103480407; -.
DR KEGG; pret:103480407; -.
DR CTD; 557584; -.
DR GeneTree; ENSGT00940000153763; -.
DR OMA; WHILEAP; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000010232; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.10.580.20; -; 1.
DR Gene3D; 3.90.1280.20; -; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF7; H(+)_CL(-) EXCHANGE TRANSPORTER 5; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 152..173
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 237..259
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 280..302
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 308..324
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 336..360
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 410..431
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 451..470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 524..545
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 551..570
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 683..747
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 780..837
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 57..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 92481 MW; 6F47056BE53268E9 CRC64;
MFQFLSRLYR NYALVVDRAP GRMENPGYSS GFDGLHHPSD DDDDEMVDIA GATLDFSTTD
DVPPLSSGGY DEYSAGSSSS SRAAGMNGSG PTKLVDPLDD PLPGVGTYED FNTIDWVREK
SKDRDRHREI TNKSRESTVA LLHSVSDAFS GWLLMLLVGL MAGALAGGID IAAHWMTDLK
EGVCLIGFWF NHEHCCWTSN ETTFQERDRC PQWKSWAELI AGTAQGPFAY IVNYLMYIFW
ALLFSFLAVT LVRAFAPYAC GSGIPEIKTI LSGFIIRGYL GKWTLIIKTI TLVLAVSSGL
SLGKEGPLVH VACCCANILC HLFTKYRKNE AKRREVLSAA AAVGVSVAFG APIGGVLFSL
EEVSYYFPLK TLWRSFFAAL VAAFTLRSIN PFGNSRLVLF YVEFHAPWHL VELAPFILLG
IFGGLWGALF IKANIAWCRT RKTTRLGHYP VIEVLLVTAV TALIAFPNSY TRMSGAELIS
ELFNDCSLLD SSQLCGYKQP VNTSETGVDN SLADRPAGAG LCTALWQLAL ALIFKMLITV
ITFGMKVPSG LFIPSMAVGA IAGRLLGVGM EQLAYYNHDW LIFRGWCSPG ADCITPGLYA
MVGAAACLGG VTRMTVSLVV IMFELTGGLE YIVPLMAATM TSKWVADAFG REGIYEAHIR
LNGYPFLEPK EEFEHSSLAV DVMRPRRGDP ALAVLTQDGM TVGEVETLVE STHYSGFPVV
VSQESQRLVG FVLRRDLLIS IDNARKRQDG IVSASLVVFT EHCPAQPPEA PPPLRLRGIM
DLSPFTVTDH TPMDITVDIF RKLGLRQCLV THNGRLLGII TKKDILKHMA QIANRDPDSI
LFN
//
