ID   A0A3P9P2D6_POERE        Unreviewed;       759 AA.
AC   A0A3P9P2D6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Forkhead box protein P2 {ECO:0000256|ARBA:ARBA00040052};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000015997.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000015997.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000015997.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   AlphaFoldDB; A0A3P9P2D6; -.
DR   STRING; 8081.ENSPREP00000015997; -.
DR   Ensembl; ENSPRET00000016162.1; ENSPREP00000015997.1; ENSPREG00000010330.1.
DR   GeneTree; ENSGT00940000155480; -.
DR   OMA; XHLNNEH; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000010330; Expressed in head.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR   CDD; cd20065; FH_FOXP2; 1.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR047412; FH_FOXP1_P2.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR032354; FOXP-CC.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR   PANTHER; PTHR45796:SF1; FORKHEAD BOX PROTEIN P2; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF16159; FOXP-CC; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          501..574
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        501..574
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          416..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          692..711
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          718..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..298
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..320
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   759 AA;  81922 MW;  A3605EA85FB96B87 CRC64;
     MMQESATETI SNSSMSQNGM STLSSSQLEA GSRDGRSSAG DTSSEVSTVE LLHLQQQQAL
     QAARQLLLQQ PGSGLKSPKS QDKQRPLQVP VSVAMMSPQV ITPQQMQQIL QQQVLSPQQL
     QALLQQQQAV MLQQVQQTTH SHTHTHQQQQ QQQQQQLAAQ QLVFQQQLLQ MQQLQQQQHL
     LNMQRQGLLS LPGPAPGQAA LPGQTLPPPG GLSPAELQQL WKDVTGVGGG GGGGHAMEDN
     GIKHSGGGIG SANTGTGVVS SGLDLSTNNS TSTTSSSNPA KASPPISHHA ITNGQSPILN
     HRRERERERE RRERNSLHEE SGGTHPLYGH GVCKWPGCEN MCEDFGQFLK HLNSEHALDD
     RSTAQCRVQM QVVQQLEIQL SKERERLQAM MTHLHMRPSE PKSSPKPLNL VSSVTMSKNL
     PSTSPPNLPQ TPTTPTAPIT PMAAMPQVPS VLGGANVPSM GAMRRRHSDK YSMPLSSGGD
     TVFIFPEIAP NYEFYKNADV RPPFTYATLI RQAIMDSADM QLTLNEIYSW FTRTFAYFRR
     NAATWKNAVR HNLSLHKCFV RVENVKGAVW TVDEVEYQKR RSQKITGSPS LVKNLPSSLG
     YGTALNASLQ AALAETSLPL LGTPGLMSSA AGPMGGSCHG LLGGDPSGPI GGSPPGLLGG
     SPPGLLGISP PGTLSCSPQT MLQSAHEELN GSLDHLDTNG HSSPGYSPPV HMPPVHVKEE
     PLNMDDDDCP MSLVTTANHS PELDDDRELE EGNLSEDLE
//