ID A0A3P9P2T6_POERE Unreviewed; 1202 AA.
AC A0A3P9P2T6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Neural cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSPREP00000016146.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000016146.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000016146.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000016146.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: This protein is a cell adhesion molecule involved in neuron-
CC neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
CC {ECO:0000256|ARBA:ARBA00003000}.
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DR RefSeq; XP_008423202.1; XM_008424980.2.
DR AlphaFoldDB; A0A3P9P2T6; -.
DR Ensembl; ENSPRET00000016314.1; ENSPREP00000016146.1; ENSPREG00000010771.1.
DR GeneID; 103474177; -.
DR CTD; 114442; -.
DR GeneTree; ENSGT00940000155743; -.
DR OrthoDB; 5233206at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000010771; Expressed in head.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00096; Ig; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR009138; Neural_cell_adh.
DR PANTHER; PTHR12231; CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN; 1.
DR PANTHER; PTHR12231:SF239; NEURAL CELL ADHESION MOLECULE 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 1.
DR PRINTS; PR01838; NCAMFAMILY.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1202
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018054999"
FT TRANSMEM 716..741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..110
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 115..202
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 209..295
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 302..405
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 410..498
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 504..602
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 604..700
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 584..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1110..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..876
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..907
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..975
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1202 AA; 130599 MW; 3FA56DB11570DE47 CRC64;
MVQTRNVFLA LLLVGSTVSL EVQITPTHGE ISLGESKFFM CDVVGVAKHV DWYGPSGERI
APNRPDLTVT RNDESSSTLT FYEAKTDSAG TYKCVATNGD QQAEATVKVK IFQRITFTNA
PPRQEFTEGD NANIVCDVTS SPPPTVFWKY KGAKIQMEKD VRFKVLSNNH LQIRGIKKTD
EGMYMCEARL MARGEIDLRP ISVVVNVLPT IRIWQSEVNA TAEVAQPATL TCAVDGYPEP
MVTWIRNGVE LRDEEKYGFN EDGSEMTIMD VTKLDEGEYT CVAKNKAGES EKELSLRVFV
KPKITYIVNR TASETEEQVT VTCEASGDPT PTISWSYGEQ VFTEGDQASW TRPEQHKSPD
GNVVVRSDAR VSSLTLKYVK YTDAGQYLCT ARSAIGEDEQ TAYLEVRYTP KIHGTVAVYT
WEGNPVNISC EVKAFPTDVS IVWLRDGLQL PNSNTTNIKI FRTPLSSYLQ ITPESENDFG
SYNCTASNEM GTESKEFLLI QAEVPSSLVI DEVRPFSTTA LIQFGEPEST GGVPVLKYRA
EWRMQGRSSW TQKVYEVQDD FVNEVTITGL KPESRYEVKL SAINGKGEGE SSPTERFKTE
PVRNPNPPKL EGSVEPKGNS LKVSWLKQDD GGSPILHYLI RYKPIQTSQW KPEIRMPSGS
DYVVLRGLDW DTEYDVYVVA ENLKGKSPPA TMSFRTSAEP EAFPDMGDEG PFFMNIILWA
GILVVVFVLL LLAVDVTCYF VNKCGLIMCL CGKSGTGTKG HVLEEGKAAF VKDESKEPIV
EVRTEDECTA NHNAAGPIEP NETTPLTKPE LVASLALDTP SSVATNSDTA TATIDPAQES
PSSETTTLTC SLSTLANEPS PTPLTAPAPT PESNTAPPTP VVSSTAVEAK MAPLLEERGR
KTSEEPEKTS NPPATPEQCR PQKSGTPIPP KRRHSPKLAA LNAKNSPPVS PLAVSSPPPI
PDGKKPAPSP PVNKPTPRAN AVALSKETLA QTAATTANTA LPKPDPESKP GLPDSTAYTF
TDFDTDNPTG NNIPTPKPTT INAPSDIPNA VEDPYLKNPI TLLADIPSPL PITAIALAVP
NDLLIPGSDL YDLTAPDGVH KNADLELELR NGAGRPSRPR SDLINLESPS AAPSLPSGDQ
ADFPPSGPVL EASETLKTAP PVNDEKIFAD EKSKLEEGDL PNPLITSAHN SVIQTNTTES
KV
//
