ID   A0A3P9P363_POERE        Unreviewed;      1121 AA.
AC   A0A3P9P363;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Leptin receptor {ECO:0000313|Ensembl:ENSPREP00000016138.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000016138.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000016138.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000016138.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   STRING; 8081.ENSPREP00000016138; -.
DR   Ensembl; ENSPRET00000016308.1; ENSPREP00000016138.1; ENSPREG00000010068.1.
DR   GeneTree; ENSGT00730000111209; -.
DR   OMA; FPPHCLF; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000010068; Expressed in caudal fin and 1 other cell type or tissue.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR041182; LEP-R_IGD.
DR   PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR23037:SF7; INTERLEUKIN-21 RECEPTOR; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF18589; ObR_Ig; 1.
DR   SMART; SM00060; FN3; 2.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          200..298
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          290..422
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          493..584
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          50..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          932..1031
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        932..955
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        958..974
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        975..993
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1003..1019
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1121 AA;  126265 MW;  BDCC738C247395B4 CRC64;
     VGDGMKRSIQ TNSVQCLRPG APVXPGALDV PWQDELCCDS PTAYTYIEEG TSQSDLNXPQ
     SPSCKFRSSS AESKPPAASP KGVICKCGFL SGTCLDVLCR FDESWSNLTC DLKSSGLSSG
     LMKPILLIIK FAPLSSSPEN DTDHHASEHQ VVCDAEDSLM CSIHLNSTRI SAVWLTVNVS
     NVLAPPVLLR ISPRSVKPSP PFNLSHSQTV EGDLILSWKE PLDFSDNLLA YEIRYSHENT
     NKNTHKNWQV VSALEKPNVS LDLKPLLKYT IQVRCTTQTQ PELWSDWSDP YYITLNKVSY
     IPQKVVARAG DNVTVYCVLN GQSANANTAM WSLNRREPLD PSLYHPVNQR VSQITFTASE
     TGLSDLLTCT QEWNIPYSKI YVEGGFISIT CVTNGDIDTM TCRWENKEWE IVKLRSKSAE
     MSCDEMEERV RGGEDVGEMG HECMPIKTTE KFCTFHPLKM NCYKLWLELH TRLGVIRCKP
     VYVSPINHVK PYPPTDVTAV SRSSGILRVS WKPPSLPVEG LQCQFRYYLL GVLEKWKFEK
     PVWVPWAEVE VPDMCQIYVV QVRCMHTSGI GYWSEWTPER GPDFWRIRQD EPDRNQSNIT
     LLFEANKGHN SNWNTYCXDG FIVQHQASNG SVLRRQIDMV SSYSFEWNQE LHIVTVEAYN
     SLGSSVNNVN MTLEKQPKRR CLHSFHVLVM NSTCVSLSWS LLHISSVPLF MVVQWFPRKQ
     QDFEDFGLSK RTWAKLSYTE PPTQLRGDFF SSEEYAFHLY PVFADGEGEP VVTIVKTGNP
     PAYMMLMFIS LLCIAVFVTL VLSQNQMKKF VWKDVPNPNR CSWAKGLDFK TMDGFEYLFR
     PPEGLQAXPL APEKISKVTV VNKTLTKAFV QTPTLLAPPS VVASTNSFLP CLDPRTGQLL
     ECEMALGSDT SPDPLTTSDI IINELQPVNA LVEQSSGTTN SSTQSAVTYS KVLHTDTNPD
     HPPLHLHYKE GSRSSYSDEG NFSANNSDTS ETFPGGLWEV DSYHGTESDD PRRSYSYNSE
     KELSEASEQE DDIDVGQKKA LHYLBIGHPP EDEENEEEES QTELLKSAHL IREDCSVELY
     PLLSPDESTD PKTLVQVSTC SFASLYMPQY RKPDVNHIPH T
//