ID A0A3P9P3Q3_POERE Unreviewed; 1970 AA.
AC A0A3P9P3Q3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Myosin-6 {ECO:0000313|Ensembl:ENSPREP00000016462.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000016462.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000016462.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000016462.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 8081.ENSPREP00000016462; -.
DR Ensembl; ENSPRET00000016640.1; ENSPREP00000016462.1; ENSPREG00000011013.1.
DR GeneTree; ENSGT00940000154805; -.
DR OMA; DMKKFCF; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000011013; Expressed in head.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF15; SLOW MYOSIN HEAVY CHAIN 1-RELATED; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..780
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 657..679
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 844..1925
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1970 AA; 226670 MW; 8FCD6D3022563889 CRC64;
MSGDALMAEF GPAASFLRKS DKERLEAQTR PFDMKKACFV PDPEVEYVKA TVTSRDGDKV
TVETETGKTV TVKEVDVHPQ NPPKFDKIED MAMFTFLHEP AVLFNLKERY AAWMIYTYSG
LFCVTVNPYK WLPVYDKSVV NAYRGKKRSE APPHIYSISD NAYQYMLSDR ENQSILITGE
SGAGKTVNTK RVIQYFASIA AVAGKKDPNQ EKKGTLEDQI IQANPALEAF GNAKTIRNDN
SSRFGKFIRI HFGVSGKLAS ADIETYLLEK SRVTYQLKAE RDYHIFYQIL SQRKPELLEM
LLITNNPYDY AYISQGETTV TSINDADELI ATDEAFDVLG FTQEEKNGIY KLTGAIMHYG
NMKFKQKQRE EQAEPDGTED VDKVAYLMGL NSADLIKGLC HPRVKVGNEW VTKGQNVQQV
YYSIGALAKS VYEKMFLWMV VRINQSLDTK QPRQYFIGVL DIAGFEIFDF NTFEQLCINY
TNEKLQQFFN HHMFVLEQEE YKKEGIVWEF IDFGMDLAAC IELIEKPMGI MSILEEECMF
PKASDLTFKA KLYDNHLGKS PNFQKPRVVK GKPEAHFSLI HYAGTVDYNI GNWLVKNKDP
LNETVVGLYQ KSNLKLLSML FAGYAGADSD AGGKGGKGGK KKGSSFQTVS ALHRENLNKL
MTNLRSTHPH FVRCIIPNET KTPGAMENPL VMHQLRCNGV LEGIRICRKG FPNRIQYGDF
KQRYRILNPS AIPEGQFIDN KKAAEKLLGS LDIDHEQYKL GHTKVFFKAG LLGVLEEMRD
DRLALIITGF QARSRGLLAR IEFQKIVERR EALLVIQWNI RAFMGVKNWP WMKMFFKIKP
LLKSAETEKE MANMKEEFTK LKEAYAKSEA RKKELEEKMV TLLQEKNDLQ LQFQSEQDNL
ADAEERCEGL IKSKIQLEAK AKELTERLED EEEMNAELTA KKRKLEDECS ELKKDIDDLE
LTLAKVEKEK HATENKVKNL TEEMAALDEI IAKLTKEKKA LQEAHQQTLD DLQSEEDKVN
SLTKAKVKLE QQVDDLEGSL EQEKKIRMDL ERAKRKLEGD LKLTQENVMD LENDKQQLEE
KLKKKDFEIS QQLGKIEDEQ AMGAQLQKKL KELQARIEEL EEELEAERAA RAKVEKQRAD
LARELEEISE RLEEAGGATA VQIELNKKRE AEFQKMRRDL EEATLQHEAT TAALRKKSAD
SVADLGEQID NLQRVKQKLE KEKSELKLEL DDVISNMEQI AKVKTNLEKM CRTLEDQVSE
YRTKSEEAQR SINDFTMQKA KLQTENGELL RQMEEKDSLV SQLTRGKLSY TQQVEDLKRQ
LEEEVKAKNA LAHAVQSARH DCDLLREQFE EEQEAKAEFQ RSLSKANSEV AQWRTKYETD
AIQRTEELEE AKKKLAQRLQ DAEEAAEAAN AKCSSLEKTK HRLQGEIEDL MVDVERSNAA
AAALDKKQRN FDKVLAEWKQ KYEESQTELE SSQKEARSLS TELFKLKNSY EESLDHLETM
KRENKNLQEE ISDLTEQLGE GGKSIHELEK IRKQLEQEKA EIQTALEEAE GSLEHEEGKI
LRTQLEFNQV KADIERKLAE KDEEMEQAKR NQQRTVDTLQ GSLEAETRSR NEALRLKKKM
EGDLNEMEIQ LSQANRQAAE AQKQLKGVHA HLKDSQLQLD DALRSNDDLK ENIAIVERRN
NLLQAELDEL RSLVEQTERG RKLAEQELLD VSERVQLLHS QNTSLLNQKK KLEGDIAQIQ
NEVEEAVQEC RNAEEKAKKA ITDAAMMAEE LKKEQDTCAH LERMKKNMEQ TIKDLQHRLD
EAEQIAMKGG KKQVQKLEAR VRELENEIDM EQRKSSDSIK GVRKYERRIK ELTYQTEEDK
KNLARVQDLV DKLQMKVKSY KRSAEEAEEQ SNVNLSKLRK LQHELEEAEE RADIAESQVN
KLRVKSRDAG AKVRRRTCQG FNICCSKSFC KRMTSSVCIF FFFQKSHDEE
//
