ID A0A3P9P4D7_POERE Unreviewed; 3030 AA.
AC A0A3P9P4D7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Neurobeachin-like {ECO:0000313|Ensembl:ENSPREP00000016669.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000016669.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000016669.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000016669.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSPRET00000016849.1; ENSPREP00000016669.1; ENSPREG00000010997.1.
DR GeneTree; ENSGT00940000154934; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000010997; Expressed in head.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF62; NEUROBEACHIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 2232..2340
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2359..2647
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1284..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1553..1576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1635..1774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1840..1862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1878..1899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2182..2202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..40
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1555..1576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1635..1657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1737..1774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1842..1862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3030 AA; 334698 MW; 24218F420FC2490D CRC64;
MSSETPASAP PGSASSLTDT DQDSHPPLPP PPPAGSSAQP PPPQQQQQQQ QQQVAAGAGS
GSTGEKMVSA AGSMVLPAGV INPAVPIRNI QMKFAVVVGL IQVGEVSNRD IVETVLNLLV
GGEFDLEMNF IIQEAESIGC MVELLSHCEV TCQAEIWSMF TAILRKSVRN LQTSTEVGLI
QQVLLKMSTV DDMIADLLVD MLGVLASYSI TVKELKLLFS MLRGENGIWP RHAIKLLSVL
NQMPQRHGPD TFFNFPGRSA AAIALPPIAK WPYQNGFTIN TWFRQDPLNN INVDKDKPYL
YCFRTSKGIG YSAHFVGNCL IVTSLKSKGK GFQHCVKYDF QPRKWYMISI VHIYNRWRNS
EIRCYVNGQL VSYGDMAWHV NTNDSYDKCF LGSSETADAN RVFCGQLGAI YVFSEALNPA
QIFAIHQLGP GYKSTFKFKS ESDIHLAEHH KQVLYDGKLA SSISFTYNAK ATDAQLCLES
SPRENPSIFV HSPHALMLQD VKAIVTHSIH SAIHSIGGIQ VLFPLFAQLD YKQLNDSSVD
TTVCATLLAF LVELLKSSVA MQEQMLGGKG FLVIGYLLEK SSRIHITRAV LEQFLSFAKY
LDGLPHGAPL LKQLCDHVLF NAAIWIHTPA KVQLSLYTYL SSEFIGTATI YTTIRRVGTV
LQLMHTLKYY YWAINPLECS GISPKGLDGP RPSQKEIISL RAFMLLFLKQ LILKDRGVKE
DELQSILNYL LTMHEDENIH DVLQLLVALM SEHPASMIPA FDQRNGIRVI CKLLASKSES
IRVQALKVLG YFLKHLGHKR KVEIMHTHSL FTLLGERLMM HTNTVSITTY NTLYEILTEQ
VCTQVVHKPH PEPDSTVKIQ NPMILKVVAT LLKNSTPSSE LMEVRRLFLS DMIKLFSNSR
ENRRCLLQCS VWQDWMFSLG YINPKNPEEQ KITEMVYNIF RILLYHAIKY EWGGWRVWVD
TLSIAHSKVT YEAHKEYLAK MYEEYQRQEE ENMKKGKKGS VSTISGLSAT PAPVVNGNLE
IDDNSQTQTP ESEAEYGEGA GGDSRNLLAE GSVKRPNGEA LTPGEQSAGP GVRVEVHDLL
VDIKAEKVEA TEVKLDDLDL SPEGLSGSVG GSGGGVGIEN GPLVEVDSLL DSSYCSVVPN
LNGNLVPKDD TAGSRVGIGT SLGLSRVSME DDGNMGPLIT LADEKDSVPS NNGFLFSKVD
EKLLPALAST DPLVLPSPDQ PAPSGSIPAH STTSASDDLS LLAHMTSCDS DLTQTQSHAP
GELPEDGPFK IQSPLADISS IAEAESQNQL QGATRPEFPE GEGASGPEGE TAGLKTGGDT
ASTTSDTERS DDGKDKDIKK IQTTATTQAL HGRTAAQLER DLRVDLGFRG MPMTEEQRRQ
FSPGPRTTMF RIPEFKWSPM HQRLLTDLLF ALETDVHVWR SHSTKSVMDF VNSNENIIFV
HNTIHLISQM VDNIIIACGG ILPLLSAATS PSTELENIEA TQGMSSETAV TFLSRLMAMV
DVLVFASSLN FSEIEAEKNM SSGGLMRQCL RLVCCVAVRN CLECRQRQRD RSCKSSLTSS
KSQDSLHSAS TASKQDPDRL LQDVDINRLR AVVFRDVDDS KQAQFLALAV VYFISVLMVS
KYRDILEPQR EIGRSTSLSG RSIRHEINSP TSTEHPSTAF SDRDKQTPTP VDDSPLAGLP
HTDSGIGEEG HVAGSLNGSE VGLGGLGLGL VGRETDRDRD RDNGGGGGGG TDLLCSLSSD
VRRSQESLLD SPHDPRSTPN SSQAPPSSIS SISQTNKGIN VKEILKSLVA APIDGTELGQ
ESGPTPYHPD PALKTHPMLP MQFHSFDRSV VVPVKKPPPG SLSVNTVGTP TTSGSATPGS
TPNIFAAATA TPKSMINTTG AADSASSSSS SSSSFVNGAT SKNLPAVQTV APMPEDTMEN
MSAYCEVAQC ALRSGQTPPE LKSFSSLAGF QAAPRDAGQC FSITTKLERA LEKVAPLLRE
IFVDFAPFLS RTLLGSHGQE LLIEGTGLVC MKSSTSVVEL VMLLCSQEWQ NSIQKNAGLA
FIELINEGRL LCHAMKDHIV RVANEAEFIL NRQRAEDVHK HAEFESNCAQ YAADRREEEK
MCDHLISAAK HRDHVTANQL KQKILNILTN KHGAWGTMSQ SQLHDFWRLD YWEDDLRRRR
RFVRNAFGST HADISLKALD EYGTEEDEEE GGAKSKKNFR SQSVVTQNPE AELMLEGDDD
AVSLLQEKEI DNLAGPVVLS TPAQLVAPVV VARGTLSITT TEIYFEVDEE DPTFKKMDAK
VLAYSEGLHG KWMFSEIRAV FSRRYLLQNT GLEVFMANRT SVMFNFPDQA TVKRVVYSLP
RVGVGTSYGL PQARRISLAT PRQLFKSSNM TQRWQRREIS NFEYLMFLNT IAGRTYNDLN
QYPVFPWVLT NYDSEELDLT LPGNFRDLSK PIGALNPKRA AFYAERYETW DDDGTPSHHY
TTLYSTAHST LMWMVRIEPF TTFFLNANDG KFDHPDRAFS GIGRGWRNCQ RDTADVKELI
PEFYYLPEMF VNSNEYELGV RDDGVPVCDV ELPVWAKKPE DFVRINRMAL ESEFVSCQLH
QWIDLIFGYK QRGPEAVRAL NVFNFLSYEG AVNLDILDAA QREVIETQIQ VSGQVPSQLL
IEPHPPRSSA MHLCFLPQSP LMFKDQMQQD VIMVLKFPSN SPVTHVAANT LPHLSIPAAV
TVTCSRLFAV NRWHNTVGLR GAPGYSLEQA HHLPIEMDPL IANNSGVNKR QITDLVDQSI
QINTHCFVVT ADNRYILVCG FWDKSFRVYS TETGKLTQIV FGHWDVVTCL ARSESYIGGD
CYIVSGSRDA TLLLWYWSGR HHIIGDNPNN SDYPAPRAVL TGHDHEVVCV SVCAELGLVI
SGAKEGPCLV HTITGDLLRA LEGPELCMRP RLISVSSEGH CVIYYERGRF CNFSINGKLL
AQMEVNDSSR AILLSSDGQN LVTGGDNGVV EVWQACDFKQ LYIYPGCDAG IRAMDLSHDQ
RTLITGMASG SIVAFNIDFN RWHYEHQNRY
//
