ID   A0A3P9P591_POERE        Unreviewed;       644 AA.
AC   A0A3P9P591;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Centrosomal protein of 76 kDa {ECO:0000256|ARBA:ARBA00015706};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000016992.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000016992.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000016992.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Centrosomal protein involved in regulation of centriole
CC       duplication. Required to limit centriole duplication to once per cell
CC       cycle by preventing centriole reduplication.
CC       {ECO:0000256|ARBA:ARBA00024729}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}.
CC   -!- SIMILARITY: Belongs to the CEP76 family.
CC       {ECO:0000256|ARBA:ARBA00005400}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3P9P591; -.
DR   STRING; 8081.ENSPREP00000016992; -.
DR   Ensembl; ENSPRET00000017172.1; ENSPREP00000016992.1; ENSPREG00000011475.1.
DR   GeneTree; ENSGT00390000000781; -.
DR   OMA; RRWWSEY; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000011475; Expressed in caudal fin and 1 other cell type or tissue.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.620.30; -; 1.
DR   InterPro; IPR028926; CEP76-C2.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR46436; CENTROSOMAL PROTEIN OF 76 KDA; 1.
DR   PANTHER; PTHR46436:SF1; CENTROSOMAL PROTEIN OF 76 KDA; 1.
DR   Pfam; PF15627; CEP76-C2; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT   DOMAIN          85..242
FT                   /note="CEP76 C2"
FT                   /evidence="ECO:0000259|Pfam:PF15627"
SQ   SEQUENCE   644 AA;  72675 MW;  45868771972D2030 CRC64;
     MDVHGRIREV LAETIKDDEG SVHRPLSEGD FVRALQRRGI IDDVMRDLHF TQVCHHFASR
     VKLRLTFKDV CFTFLMYSTH LKKANLDPSR RYLYLQVLGG KAFLEHLQDS EPLPGQVCPT
     FTLYLHFRNQ RFRSKPVPCA CEPDLKEGFL LEIHRDSFGD GSKMVDATAM LSMCDTVHLV
     LIKTDTSGET TLVSSYFLDW RIVLGSPSCK TCFAMEMMGV GSESKIPAGV LTVSLELFPP
     LQETLNTDII VTQQSLERQR TAEKERLFLV YAKQWWREFL EIRPSHQSKL VKIFAQDENG
     VNRPVCSYVR VLRAGRLLES PRQAARFVSL LAHERAPVVG GGGKQEQWCT LMAFLCRGKG
     DCEDHATLLC SLLLGFGLDA YVCVGTKVNS GPHTWVLTRG TDGSITFWES LTAHRYLHRP
     IDPDAPPLVP QPKPSSPYRT VGCVFNHQTL LANCQPSDAV ELCVFDFQNQ SRWKAMSEEA
     LKSVCAPGST SSLPPLPPLC ASSLDSAEVS NHLELEMRFL VSEHRKDLDL ATVWDDHLSY
     LLSSALSAYE MERCTGVSCG NEEFQDAVRR AVPDGHTFKG FPIHFLHRNA RRAFATCLRS
     PFCEEIVCCR GDHVRLAVRV RVFVYPENAC AVWMMFACKY RSVL
//