ID   A0A3P9P718_POERE        Unreviewed;      1265 AA.
AC   A0A3P9P718;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=DENN domain containing 3 {ECO:0000313|Ensembl:ENSPREP00000017589.1};
GN   Name=DENND3 {ECO:0000313|Ensembl:ENSPREP00000017589.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000017589.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000017589.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000017589.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_008420362.1; XM_008422140.1.
DR   RefSeq; XP_008420363.1; XM_008422141.2.
DR   AlphaFoldDB; A0A3P9P718; -.
DR   STRING; 8081.ENSPREP00000017589; -.
DR   Ensembl; ENSPRET00000017776.1; ENSPREP00000017589.1; ENSPREG00000011896.1.
DR   GeneID; 103472471; -.
DR   KEGG; pret:103472471; -.
DR   CTD; 797970; -.
DR   GeneTree; ENSGT00940000155784; -.
DR   OMA; GTSKVNC; -.
DR   OrthoDB; 5354449at2759; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000011896; Expressed in caudal fin and 1 other cell type or tissue.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR12296:SF21; DENN DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT   DOMAIN          82..500
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          74..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          502..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1265 AA;  143159 MW;  6F57129CA7FB363A CRC64;
     MAELPSGLLE ACVVVGAPSD KLRELPQHTK SSELPLLDPE VLQVHAPPFV SIEANSNHVI
     GPAFSRVQRR RSFIKKKRRD RAAEGVSNGD SSSRHEASPV PSTEDISVPK DLDLIALPQL
     CFPDGLQLAS EQKDDAYHFL VFTDLFGNRT HGVVVQYYRA VQSVQDNVFQ NGHRWNAPKS
     RLFAPFAVCI ISKFPYYNAL KDSLSCLLVQ LRTARQADLE ETIREFSAKL SLVPLPPPGQ
     LHVSFSLRPL QVVLPSRDDQ DSPVVDLNLH LPLLCFTHTA LLQVLSCLLQ EQRIVFFSSD
     WARLTLVAES LLLYLQPLSW QQPYVPVLAR GMLDFLMAPT AFLMGCHINH FEEIAAETED
     LILVNVDDGL IQTSWSEAVD LPALPLAAAE CFISRAESLQ IQYDLELCHL GTGTDVNSLR
     SQRRGWQQKL NSQIQNIALE LVVNIFRGVQ DFLNHEHRVF NSEEFLRTRE PDDQLFYRKV
     LETHIFHSFL RDRLNRKRDS FSRMEQMTQS QSHRNRAMTE SPRRPPMSEL SRAGPDRKLS
     KRLGASLPNL DQPINESVAL NANRLLSIRK ISPDSGLKFL QKPLKVFRLP EFPPPLAYHY
     VQNYYSDMVA SLGKTISATP PDESALLARY HYLRGLVNTV SNRRLDALED FHSLYKTDAE
     IFPSQMVNSL IDSLPDVERV QADRRPEIKR LISRLKREQE RERATQGTGQ EDAAVKRFQL
     PKKYMHLEEF VKCVQESGIV KDQGTIHRLF DALTVGNQKQ VGPDLFRVFY TIWKETEAEA
     QEVCLPASVL EHIDAAECVF KLSSSVKTSR GVGKIAMTQR RLFLLTDGRP GYVEVAQYRD
     LEEVRVSSAP FLVLRIPSLK IRVHGRKETF EANLKTETEL WNLMVKEMWA GRSIADRHKD
     PQYMQQALTN ALLMDAVVGS LQSSKAIYAA SKLAYFDRMS LEAQMMVPST TSETLKHKIN
     PSVEFAVPQA VDVLLYTPGQ LWVSVGGGKV MVYDASSWSL IQTCQVGNAR LNCMLGVDRD
     QVWMGSEDCV IYIISLVSMV CNRQLTEHRA EVTGLALDNE KYCHKVAYSC SAEGTVMAWE
     VSTLQVKRHF RLSCDRLQSV YSCGGVLWCC ARDGIMEVWR NGTLKQHINL PEQQRVTFSS
     ALLIPESEEL WSVCVDSAEV YIWHIKNTSR PINRVMLQDC TGCYCMIQVK NQVWVGGMGR
     SSTKGKIYIL DTERYEVLKE LHGHIDKVTA LCSAEDRYVL SGAAKHDGKV AIWKVEDRGL
     DSSKC
//