ID A0A3P9P777_POERE Unreviewed; 378 AA.
AC A0A3P9P777;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Transmembrane and coiled-coil domains 4 {ECO:0000313|Ensembl:ENSPREP00000017649.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000017649.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000017649.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000017649.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
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DR RefSeq; XP_008411402.1; XM_008413180.2.
DR AlphaFoldDB; A0A3P9P777; -.
DR STRING; 8081.ENSPREP00000017649; -.
DR Ensembl; ENSPRET00000017836.1; ENSPREP00000017649.1; ENSPREG00000011936.1.
DR GeneID; 103467103; -.
DR KEGG; pret:103467103; -.
DR CTD; 255104; -.
DR GeneTree; ENSGT00390000001400; -.
DR OrthoDB; 8526at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000011936; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF3; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 41134 MW; 3DA15C4993D0B1D4 CRC64;
MEEKQSNADF SPDPGGAAAA GHEPEKITSH QLTEQSRFAF AALCAVSVGQ LFSGSENSAF
REQYLQDLVQ WLGLDQSVMP VMGAFLSGLG SEGTDTFLSI LQADPLVAAG VMPIIQGKRP
VSLIGFSLGA RVIYYCLQEL ASDKGSEGVV EDVVLLGAPV DGSEKSWERM VRVVAGRIVN
GYCRGDWLLG FLYRSSAAQL SVAGLQPINI QDHRIINVDL SSVVKGHLDY MRQMDTILVA
VGVPTKEVAG ASFVLPQSVR ATQKPVDDLD RAEEQHQASE TQNPAEKDKT SSQESADWRD
ETEDMGDGWD IPDITDLLDS LNETEPNDGV SVLNNVSPNN ATSSNFIAQN SREEAEPDDE
QISWSWNDTH WTADHLHK
//
