ID A0A3P9P963_POERE Unreviewed; 696 AA.
AC A0A3P9P963;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Sortilin related VPS10 domain containing receptor 1 {ECO:0000313|Ensembl:ENSPREP00000018352.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000018352.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000018352.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000018352.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A3P9P963; -.
DR STRING; 8081.ENSPREP00000018352; -.
DR Ensembl; ENSPRET00000018550.1; ENSPREP00000018352.1; ENSPREG00000012399.1.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000012399; Expressed in head.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 594..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 329..385
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 696 AA; 78357 MW; 41F8BBC15F43F685 CRC64;
MIDLYEVAGI KGVFLSNKVV ENQVKTYITY NKGRDWHLLQ APTTDLQGNK VYCEQVSGPL
TGGVVGPELS SVNVSIFITS DAGNTWREVF QEEYSVFFLN QGGSLVAIRH TPLPIRHIWL
SFDEGRNWDK YSFTSSPLYV DGVLGEPGED ILIMTIFGHF SHRSEWQLLK IDFRPIFEKR
CTSEDYVTWQ LDNEGEVCIM GMKRIFQKLR ANVRCVKARD QYISQMSDSC ACTEADFECD
YGFERQVDGS CTSAFWFVPS ASTRDCITGD SFFNTTGYRK ALSNNCTKGS LLKYSPRQQK
CPSQAPRGLQ LFTSEGTFVA TLGRNVTFLV FLEEGLSSMT SITVDFGDGT AISYVNISSI
DDGVKHIYNK VGIYQVSATA SNHLGFDRVF LYLHVSCHLE QVQLSAPLVV IKDKAVNFTT
TLRPSSVGTV TYFWWFDNKT EPVVTLDGAI TFTFSREGSH IVTVQALAGN TVHQDQIRVA
VYDYFRSHPL VFSSNLDEMN PGVSEWREDI GRVVKTCIVQ VTGINEDQLL VKLFPGLPTT
AEVFLVPERR SRDGGMNEKW AHLDQVLSRQ IIQKLLVNIT PLVDGSDSGH SGTAVIMLVS
VVLMGLAIFV IYKFKRKIPG MNTYATEKPD KEQEVIPAVT SIAVPNPEGD ELTSLDHVDI
QLDSKSRGIN ASMSYFWKFF FFFSLMLKWR IRHHFQ
//
