ID A0A3P9P9B6_POERE Unreviewed; 407 AA.
AC A0A3P9P9B6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein cereblon {ECO:0000256|ARBA:ARBA00014394};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000018419.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000018419.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000018419.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CRBN family.
CC {ECO:0000256|ARBA:ARBA00005293}.
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DR AlphaFoldDB; A0A3P9P9B6; -.
DR STRING; 8081.ENSPREP00000018419; -.
DR Ensembl; ENSPRET00000018620.1; ENSPREP00000018419.1; ENSPREG00000012473.1.
DR GeneTree; ENSGT00390000016404; -.
DR OMA; AYQMYDS; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000012473; Expressed in head and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd15777; CRBN_C_like; 1.
DR Gene3D; 1.20.58.1480; -; 1.
DR Gene3D; 2.30.130.40; LON domain-like; 1.
DR Gene3D; 2.170.150.20; Peptide methionine sulfoxide reductase; 1.
DR InterPro; IPR034750; CULT.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR046336; Lon_prtase_N_sf.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR PANTHER; PTHR14255; CEREBLON; 1.
DR PANTHER; PTHR14255:SF4; PROTEIN CEREBLON; 1.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR SMART; SM00464; LON; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR PROSITE; PS51788; CULT; 1.
DR PROSITE; PS51787; LON_N; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 51..281
FT /note="Lon N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51787"
FT DOMAIN 282..390
FT /note="CULT"
FT /evidence="ECO:0000259|PROSITE:PS51788"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 407 AA; 46133 MW; 6EA22D7521A32A22 CRC64;
METEDRDSDE AEKPSNITFD PSLPTSHAYL GSDMEEFHGR TVHDDDSCQT IPVLPHTAVM
LVPGQTLPLQ LFRPQEVSMM RSVIQKDRTF AVLAHSDAGE PEAEFGTTAE IYAYREEQEY
GIETVKVKAV GRQRFKVHEI RTQADGIRQA KVQILPERIL PDPLSAVQLT PLSRLHTSPS
SKLKAQSCKQ AQRWKFHCAS LTPWPPWVYS LYDSESLMNR VKKQLHEWDE NLKDDSLPTN
AVDFSYRVAA CLPIDDALRL QLLKIGSAIQ RLRCELDIMD RCTSLCCKQC QDTEITTKNE
IFSLSLYGPM AAYVNPHGYV HETLTVYKAN NLNLVGRPST LHSWFPGYAW TIAQCRTCGS
HMGWKFTATK KDLSPPRFWG LTRSAMLPRI PQGEDEDGDK GSRLFCL
//
