ID A0A3P9P9S2_POERE Unreviewed; 1482 AA.
AC A0A3P9P9S2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN4A {ECO:0000313|Ensembl:ENSPREP00000018557.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000018557.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000018557.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000018557.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR Ensembl; ENSPRET00000018758.1; ENSPREP00000018557.1; ENSPREG00000012575.1.
DR GeneTree; ENSGT00940000159417; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000012575; Expressed in head and 1 other cell type or tissue.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 22..41
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 116..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 256..283
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 382..401
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 413..431
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 503..526
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 583..606
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 792..810
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 831..853
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 859..879
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 923..943
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 992..1014
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1034..1057
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1091..1118
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1130..1148
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1160..1180
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1186..1205
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1225..1249
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1269..1289
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1317..1340
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1..288
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 382..611
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 622..783
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 790..1058
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1099..1350
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 312..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 705..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1482 AA; 169632 MW; 416A0730295D4748 CRC64;
MATILTDCVF LSMSNPPEWR KTVEYVVMVI YTFEVIIKVL SRGFCVGNFT FLRNPWNWLD
FMVISMIYLA EFVHFGNVSA LRPFRVLRVL KIITVFSGLR TTFGAVIQSM KKLRDVMILI
VFFVSVFALI GLQLFMGDLR HKCVLTLSSN SNTSEGAFNI NSNENISDFD FYTHINDSDN
YYHLPGQLDA LLCGNGSDAG TCPDGYMCLK AGRNPNYGYT SYDSFGWAFL SLFRLITQDF
WENLFHLTLR AAGKTYTIFF MVVIFLGSFY LINLILAVVA MAYAEQNRAN IAKAKQREKE
HARILKELKK REEKKVKRAA PLEKNGSASQ SHEEDTTTDD LEDNQEPRSS CRHVIADTFL
KWDCCGCWRW LKKLLHTIVM DPFMDVAITM CIVLYTILMA TEHYPMTGEF EEIISIGNLV
LTGILIAEML LKILAMDPYH YFQEGWNIFD SIIVTMSLVN LGLLDVHSVA VWQPLRLIRV
FKIAKSWPAF NMLIKIIRNS LRALVNLTLV LAIIVFLFTV FGMQFFANSY KDRVCRISLN
CELPRWHMND FFHAFLVIFR ILCGEWIETM WDCMEVAGEP MCLIFYIMVL VIGKLVVLNL
FLALLLSSFS GDNLAVTEDE GENNLQIVIN RISKGTARTK AWFWTLVGKK TNVNSDVNDV
TCEEGNKSKE VLPLTIVNSE QSVVKVQDST VTKICSEAKC DSEISKHKDD EDNEEDDQDE
QLAQGGKSLD CSDTERFPVI SVIKEVEDTP DDCFTEKCYS CCPCLDIDTS QSIGRIWLYI
RKTSIAIVES KYFKSFIIIV ILLSSAVLAF EDIYIDQRRD IKIILDYADQ VFNFVFVVEV
ILKLVAYGCK TFFSNAWCWL DFLIADVSLV LLSASILGYS ELGAIQSLRT LRALRPLRVL
SCFEGLRVMV NALVGAIPSI FNVLLICLVL WLIFSIMGVN LFAGKFYYCF NETSEEYFSP
EEVNNKTQCF DLIQTNFPEV RWKNTKLNFD NVGMGFLSLL QVSTFKGWMD IMYAAVDSRM
VEDQPAYEHS LYKYMYFICF VIFGSFFPFC LFITSLINFN QRKPKPIEIE PPIKWIPREP
PSRPTNKFQG LVFDLVTNPF FDILIMVLIG LYTLTMMVET DEQSPQMEEI LYWVNFVFIM
IFSIECCLKM IALRKHYFNV GWNIFDLVVV LLSIVGIPFA DIIEKYFVFP ALFSGARIGL
ILRLIRRAKG IRKLLFALRK SLPAVFNLCI LLFIIMFVFS IFGMSNFAYV KKGAMIDDIV
NFETFGNSMI SMFTITTLAG WDSLLYPIMN TPPDCDPDFE NPGTSVRGNC GSPAMGIVFF
TSYIIMSFLV VINIYITIIL EIFNIATEES ADPLSEDDFD MFYKTWEKFD PQASQFIHYS
ELSDLCDALP YPLRIPKPNT INLLQMDLPL VQGDRVHCLD VLIALTEEVF GESQATDELK
STMEWKFMAN IASEESLRPI VSTFRKKHEE MAEPTGDTFS SE
//
