ID   A0A3P9P9X4_POERE        Unreviewed;       832 AA.
AC   A0A3P9P9X4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSPREP00000018691.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000018691.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000018691.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000018691.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3P9P9X4; -.
DR   Ensembl; ENSPRET00000018894.1; ENSPREP00000018691.1; ENSPREG00000012455.1.
DR   GeneTree; ENSGT01100000263565; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24061:SF511; EXTRACELLULAR CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01535; VOMERONASL2R.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..832
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018199583"
FT   TRANSMEM        568..594
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        606..626
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        638..663
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        683..702
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        730..751
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        763..783
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        789..818
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          569..832
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   832 AA;  92410 MW;  E108AA46DFE0A13A CRC64;
     MRLLHVILLL FLSLFRGNHG SSAALDICAF LGEEERKSLY EDGDVVIGGL FPLHYSPVSS
     PLTYNVKPTP NTYNYARALR WMQTMTFAIK EINGRTDILP RLKLGFHIRD SCDDIPVSLK
     ASFLQDEAAG LGCEAVNRTV SPVIIGDAGS GVSMALLRSL GSFHIPLVSY FASCSCLSNQ
     REFPTFMRTM PSDAFQIKAL AQLVRYFGWT WVGVIGVESD YARFAIQLFL QESVRYGVCA
     AYTHFYPVGP SHEHIEKLLN VIQMTSSKVI INFSGEAEMQ DILREMQRQN LTGFQWIASE
     AWATSKLLWE NSASLLKGTL GFAIQRAAVI PGLQQHLAAL TPSAIHRIAF LAEFWEETFD
     CRLNGSANAH NHGLGSQQSR TPCKGTEALH DVYSPYSDVT QLRVSYNVYK AVYLVAYALQ
     DMSNCKAGEG PFVRNTCADP KNFKPWQLLH YMKVANFSAL GEEVNFDHNG DPIAYYDLMN
     WQTGPDGSLD LVKVGFYDAS LPSHLSECLN FASQALRSVC SSSCPPGSRI ARRKGEPVCC
     YDCVPCAEGE FSNTTESKVK QYLSYHEFMG VLLCAASVLG AAVSLAIIVI FYTYKDTALV
     RANNMELSFL LLVFLTICFL VGLLFLGKPS EWLCRIRYPA FGISFALCLS CLLAKTVVVL
     MAFRSRLPGS PVMKWFGAKQ QRASVLLGTA VQVIICFIWL LTSPPHANHN TDYHSSTIIV
     ECVTGSDVGF WLVLGYIGVL ACMCLVLAFL ARKLPDNFNE AKFITFSILI FFAVWVTFIP
     VYMSTVGKYI VAVHVFAILA SALGLLLCIF VPKCYIIVLK PEKNSKKFLM QR
//