ID   A0A3P9PCX8_POERE        Unreviewed;       786 AA.
AC   A0A3P9PCX8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Rap1 GTPase-activating protein 1-like {ECO:0000313|Ensembl:ENSPREP00000019659.1};
GN   Name=RAP1GAP {ECO:0000313|Ensembl:ENSPREP00000019659.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000019659.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000019659.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000019659.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSPRET00000019870.1; ENSPREP00000019659.1; ENSPREG00000013257.1.
DR   GeneTree; ENSGT00940000156138; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000013257; Expressed in head.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 6.10.140.210; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711:SF67; GTPASE ACTIVATING PROTEIN RAP1-GAP; 1.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF21022; Rap-GAP_dimer; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT   DOMAIN          172..388
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          435..538
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          557..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          618..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..464
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        481..538
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        558..574
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        618..632
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        638..657
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   786 AA;  87975 MW;  2A5398217C0D968C CRC64;
     MDEQRCPFPP PLKTEEDYIP YPSVHEVLGR RSPFPLILLP QFGGYWIEGT NHEPKEPPEA
     DXPTCPASHV KLETNSTAKI YRKNFMGKEH FNYYTMDAAL GHLVFSMKYE VIGDQEHLRL
     MLRTKYKTHH DVIPISCLTE FPNVVQMAKL VCEEVNVDRF YPVLYPKASR LIVTFDEHVI
     SNNFKFGVIY QKFGQTSEEE LFGNMEESPA FIEFLEFLGT KIELHDFKGF RGGLDVTHGQ
     TGMESVYTNF HNKEIMFHVS TKLPYTEGDS QQLQRKRHIG NDIVAIVFQE ENTPFVPDMI
     QSNFLHAYVV VQVENACSDN VTYKVSVTAR DDVPFFGPAL PDPAIFRKGP EFHEFLFTKL
     INAEYACYKA EKFAKLEERT RSALLETLYE ELHINSQSMM GLGGDEDKLE NGGGGGGGGF
     FESFKRVIRS RSQSMDAMGL SNKKSHTVST SHSGSFTHNP AESPKTPGIS LIIPGKSPTR
     KKSGPFSSRR SSAIGIENIQ EVQERSREVS PNTQKTPDCS HLSKENKSGN SSAHSSPEFA
     ATKNSLAMCC RAPSIPEAQD LSRSSSNASS FTSVVEEHDA EEEYETGLES VSCVTPVKKD
     SFVYGSAVED SSCSQGSFSA SRLQQQADGV KTSEPKGTDG QPKTERPQQE QKPSSVREIT
     EHQSLNDIVM ASHIGKMTMR RHVLFKSSFP LDIPQIPSLR FRKSLGGLHT GEIQTLSSYA
     AHLLTFILLH YSQYLSLANI LLGPIFYSLK RRCFHVSNLM IIHPNDTYSP PVGGATVIVV
     RRNNNS
//