ID A0A3P9PEA3_POERE Unreviewed; 215 AA.
AC A0A3P9PEA3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=exodeoxyribonuclease III {ECO:0000256|ARBA:ARBA00012115};
DE EC=3.1.11.2 {ECO:0000256|ARBA:ARBA00012115};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000020013.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000020013.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000020013.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.11.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000493};
CC -!- SIMILARITY: Belongs to the exonuclease superfamily. TREX family.
CC {ECO:0000256|ARBA:ARBA00025769}.
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DR AlphaFoldDB; A0A3P9PEA3; -.
DR Ensembl; ENSPRET00000020224.1; ENSPREP00000020013.1; ENSPREG00000013548.1.
DR GeneTree; ENSGT00390000012715; -.
DR OMA; VIGHNIR; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000013548; Expressed in caudal fin.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR040393; TREX1/2.
DR PANTHER; PTHR13058:SF22; EXODEOXYRIBONUCLEASE III; 1.
DR PANTHER; PTHR13058; THREE PRIME REPAIR EXONUCLEASE 1, 2; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022722};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 15..193
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
SQ SEQUENCE 215 AA; 24387 MW; 5B3FB9F781BF151B CRC64;
MQPETDEDEN FKQHPLVFFD LETTGLGQHC EIIQLAAVSA GHSLNLYVVP RCRIERRAAR
VTGFKVRGQR LYLDRRLVFT NSLREVVVSF IAFLQMLGRP LVVGHNIRHF DCPLLARALD
ELDLRAQFEG SVSGCVDTLP LARELLRDRG LQSFGQENLV RELLGINYKA HDALEDVRAL
KTLFGFLQPT AEVVRRHIQT GKVKKRHDGE ADTST
//
