ID A0A3P9PFQ3_POERE Unreviewed; 1004 AA.
AC A0A3P9PFQ3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Semaphorin 6A {ECO:0000313|Ensembl:ENSPREP00000020624.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000020624.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000020624.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000020624.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008416466.1; XM_008418244.2.
DR AlphaFoldDB; A0A3P9PFQ3; -.
DR Ensembl; ENSPRET00000020841.1; ENSPREP00000020624.1; ENSPREG00000013871.1.
DR GeneID; 103470092; -.
DR CTD; 57556; -.
DR GeneTree; ENSGT00940000156565; -.
DR OrthoDB; 5399685at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000013871; Expressed in head.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF12; SEMAPHORIN-6A; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1004
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018126454"
FT TRANSMEM 640..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..511
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 346..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1004 AA; 111688 MW; 0B8DB0FEC4B52590 CRC64;
MRSEALVLYF TLLQIAGAGF PEDSEPISIS HGNYTKQYPA FVGHKPGRNN TQRHKLDIQL
ILIMNRTLYI AARDHIYTVD TETANGDEIF FSKKMTWKSR QADVDTCRMK GKHKDECHNF
IKVLLQQNGD TLFVCGTNAF NPSCRTYKMD SLEALGEEIS GMARCPYDAK HANVALFADG
KLYSATVTDF LAIDAVIYRS LGDSPTLRTV KHDSKWLKEP YFVQAVNYGD FIYFFFREIA
MEYNTMGKVV FPRVARVCKN DRGGSPRVLE KQWTSFLKSR LNCSIPGDSH FYFNILQAVT
DVIHINGRDV VMATFSTPYN SIPGSAVCAY DMAEVARAFT GRFKEQKSPD STWTPFPEER
VPKPRPGSCA GTPSMERYKV SNEFPDDTLN FIKMHPLMDE AVPSIAHRPW FLKTMVRYRL
TRIVVDNQAG PHRNHTVVFL GSEKGIILKF LAKMNKGFLN DSLFLEELNV YNPDKCSIDG
VEDKRIIGMQ IDSKSNALWV AFTSCVVKVP LSRCERHGRC KKSCIASRDP YCGWVSEGAC
RQVTTDTKSA FEQDVEHGNT DGLGDCQNTF VALNGHHHHH HSLSLPTSAL PEAAEGPLGR
KDPPMSSDKG EDPYVAVPSQ TQPEATGVIR ESYQKGRDQL VPVTLLAIAV ILAFAMGAIF
SGLIVYCVCD HRRRDLDLTG RKEKDSLHLH SRRGSMNSVT KLTGLFETQA KDGRPEAILT
PLMHNGRLTP NAKMLIKADQ HHLDLAALPT PESTPMQPRR KPSRGSREWE RNQNLINACT
KDMPPIGSPV ISTDLPLRAS PGHIPSVVVL PLPQHQHQLP PHLQQSYQHE YVEQPHHSDL
GMAHGVMEDQ GATLEYKPGK SHMMDPDGML PPRVPQREAS LTVPPAVPQM GKRLEVHSSV
YGLRKGSASS ASGSSALKKH NTNSSNSSHL SRHHSFRVET PPPAPQRVDS IQMTTQGISL
SRQPGMITYG SLPRTGSKHL KPDVPPKPSV VSLSTKAKSS DSGT
//
