ID A0A3P9PGA9_POERE Unreviewed; 518 AA.
AC A0A3P9PGA9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Single Ig and TIR domain containing {ECO:0000313|Ensembl:ENSPREP00000020815.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000020815.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000020815.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000020815.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008410284.1; XM_008412062.2.
DR AlphaFoldDB; A0A3P9PGA9; -.
DR STRING; 8081.ENSPREP00000020815; -.
DR Ensembl; ENSPRET00000021036.1; ENSPREP00000020815.1; ENSPREG00000014090.1.
DR GeneID; 103466476; -.
DR KEGG; pret:103466476; -.
DR CTD; 59307; -.
DR GeneTree; ENSGT01090000259985; -.
DR OMA; LEQEWCT; -.
DR OrthoDB; 5349166at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000014090; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF19; SINGLE IG IL-1-RELATED RECEPTOR; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..518
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018122321"
FT TRANSMEM 230..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..105
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 119..223
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 273..417
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 518 AA; 58484 MW; F9AD029BD72D1990 CRC64;
MALLLAALLI VCGISNKAIV IGQTCVDESR FKEQVVYLGP AYELQCPLQT LQPQSLPRSL
WTWQKDCQPL QNQEGNAFLK FSSVRLEDQG NYTCTQQGNS TPSFTVRLVV KESQCVKAPE
FKPNGDPTKL WRSVGSVVKL NCTALLYWDP SEEQCETTLQ WSKDGQPLTN HTLYLHNTTS
WSPNAGRLVV SNLLEFTLRG AEEFGLYSCT VRNISADFSV QISNGPSHTA AVIAAILLLL
LLGTAAVVYS RCHLNFKLWY KNSYGDYELN DGKLYDAYIS YVNNDYDRKF INFILKPHLE
NKNGYKVHLN ENDILPNTEP SAELLMNISR SRRLIVLLSN PYLEQDWCTN NFRQGLLHLL
ELCQQPILIT LDGQFKRMSP EIKQQLSENQ HRLTLLTWRH NSVTPSSAFW KELALAMPRR
VIFHKDSAGD PQTILQDDKD PMLTLDPDYL DCRSDTDPAG DLGLRLPMHR ALACKAPVLP
AAPVEEAQAK ASDIDVSDLG SRSYEARSDF YCLVTEDI
//
