ID A0A3P9PHB3_POERE Unreviewed; 489 AA.
AC A0A3P9PHB3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Acid sensing ion channel subunit family member 4 {ECO:0000313|Ensembl:ENSPREP00000021063.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000021063.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000021063.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000021063.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Homotrimer or heterotrimer with other ASIC proteins.
CC {ECO:0000256|ARBA:ARBA00038726}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. ASIC4 subfamily. {ECO:0000256|ARBA:ARBA00038140}.
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DR AlphaFoldDB; A0A3P9PHB3; -.
DR STRING; 8081.ENSPREP00000021063; -.
DR Ensembl; ENSPRET00000021288.1; ENSPREP00000021063.1; ENSPREG00000014248.1.
DR GeneTree; ENSGT00940000159052; -.
DR OMA; IHEYCDY; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000014248; Expressed in head.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3590.10; acid-sensing ion channel 1 domain; 1.
DR Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR020903; ENaC_CS.
DR PANTHER; PTHR11690:SF13; ACID-SENSING ION CHANNEL 4; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 2.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|RuleBase:RU000679}.
FT REGION 337..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 55217 MW; D662916B1CC96E14 CRC64;
MPIEFVCKIK FAEEDEKQKS KQDGDKESLI EESCAPPAKD LAGFANSCSL HGINHIFVSG
RLGIRQTLWA LAFLTSLALF LYQAAKCAIS YLEHPHVTAL NEEATPEMVF PAVTICNINR
FRFSALTDAD IYHLANLTGL PPKNRDGHKP TDLMYPAPDM QDIFNRTGHQ LEEMLMSCNF
SGQNCSAEDF SVVYTRYGKC YTFNGNKTTS KKTKQGGMGN GLEIMLDIQQ DEYLPIWRET
NETSLEAGIR VQIHSQDEPP YIHQLGFGVS PGFQTFVSCQ EQRLTYLPQP WGNCRSTSRE
KFPGYDTYSI SACRLLCETN EVMRVCNCRM VHMPGKKRVK QNENSDGELK PRTKEKETST
LLPKTSEIDN FLVLDIFFEA LNYETIEQKK AYDVAGLLGD IGGQMGLFIG ASILTVLEIL
DYIYELMKHR LQRLLRPQKE EKKNTQPTTT VATVGLEEMK AKEPNDTTRS HPEGAYANTI
LPNHHDFAC
//
