ID A0A3P9PJB1_POERE Unreviewed; 940 AA.
AC A0A3P9PJB1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Dystrophin {ECO:0000256|ARBA:ARBA00040142};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000021952.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000021952.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000021952.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004278}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034100}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034109}.
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DR AlphaFoldDB; A0A3P9PJB1; -.
DR Ensembl; ENSPRET00000022183.1; ENSPREP00000021952.1; ENSPREG00000014502.1.
DR GeneTree; ENSGT00940000154342; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000014502; Expressed in head and 1 other cell type or tissue.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00176; SPEC; 1.
DR CDD; cd00201; WW; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF25; DYSTROPHIN; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00435; Spectrin; 1.
DR Pfam; PF00397; WW; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00150; SPEC; 2.
DR SMART; SM00456; WW; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 3.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 322..355
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 575..631
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 785..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 9..104
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 192..229
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 684..711
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 750..784
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 823..857
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 858..920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 940 AA; 108049 MW; 208D23A0CCE6AC39 CRC64;
MLRRKVYQVQ DLQAEVDGHE ELYHSLDENG QRILTSLRDP EDRVLLQRRL DNMRQRWNDL
RRKSVCLFGR SQLDSEMAPW KRLHMSLQEL LNWLRLKSQQ LEQEKPVGGD VPTVQSQLDT
HRGFKMELRA KDPVVTKALD DAGFFLSELP REPGLSQTSD ISPEERAQNV GRVLRKEADD
VVSRWDRLNV DSADWQRRLE LALDRLMELQ EAEDLLDKQL KQAEMVKQGW EPVGELLIDS
LPEHISRVKE FQEEIALIKD DVTHMNHLAS TFDPSDIQLS PSNLERIEDL NTRWRLLQVC
TLKHSHTHTP THTPAPTHTH TRSVERPFEQ GISPNNVPYY INHQTQTTCW DHPKMTELYQ
SLSDLNNVRF SAYRTAMKLR RLQKALCLDL LSMQTACEVF EQHTLKQNEQ LLDISQLMTC
LTSLYQRLEQ SHSHLVNVQL SVDMCLNWLL NVYDTGRTGK IRTLSFKTGI ISLCKAHLED
KYRFLFRQVA SATGFCDQRR LGLLLHDSIQ IPRQLGEVAS FGGSNIEPSV RSCFQFANNK
PELEASMFLD WMRLEPQSMV WLPVLHRVAA AETAKHQAKC NICKECPIIG FRYRSLKHFN
YDICQSCFFS GRVAKGHKMQ YPMVEYCTPT TSGEDVRDFA KVLKNKFRTK RYFAKHPRMG
YLPVQTILEG DNMETPGSSP QLSHDDTHSR IEHYANRLAE MENRNGSYLN DSISPNESID
DEHMLIQHYC QSLNQGSPLS QPRSPAQILI SMETEEKGEL ERVLGDLEQE NRSLQAEYDR
LKKAHDRKGL SPLPSPPEML PVSPQSARDA ELIAEAKLLR QHKGRLEARM QILEDHNKQL
ESQLHRLRQL LEQTDSKVNG TALSSPSTSS QRSDSSLPLL RVAASQTTDT MGDDEFSSPS
QDASGLEEVV EQLNNTFPHS QGKKTRKDSL LANVQLFDST
//
