ID A0A3P9PL43_POERE Unreviewed; 1121 AA.
AC A0A3P9PL43;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A5 {ECO:0000313|Ensembl:ENSPREP00000022582.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000022582.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000022582.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000022582.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
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DR RefSeq; XP_017162377.1; XM_017306888.1.
DR AlphaFoldDB; A0A3P9PL43; -.
DR STRING; 8081.ENSPREP00000022582; -.
DR Ensembl; ENSPRET00000022819.1; ENSPREP00000022582.1; ENSPREG00000015215.1.
DR GeneID; 103469545; -.
DR CTD; 559268; -.
DR GeneTree; ENSGT00940000157488; -.
DR OMA; RETEGNC; -.
DR OrthoDB; 1013180at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000015215; Expressed in head.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF20; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 510..529
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 549..573
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 593..615
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 740..758
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 788..807
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 828..852
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 888..907
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 914..933
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 965..996
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 142..420
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 479..966
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1121 AA; 126933 MW; 69CD80CA2644B683 CRC64;
MDHGDRGMRV SDLRYEEEDD HQSVYIGVPV SRGLRRKRRR RRSSREAQDM ERDRHYGHNR
HQDHDRYRDI DIEEGLMDSA EQSLQDINRT MSPAAERLRY ILSEDDDMPT PTLFTEMDTL
QREGDELEWK ESARWVKFEE KVEEGGERWS KPHVSTLSLH SLFELRTCLQ TGTVLLDLDG
YSLPQIVDDI IERQIEEGML SPELREKISF VLLRKHRHQT KKPIHRSLAD MGKSGSSASR
SVPPRGGMGP GPGPGPGQGQ GPNFNRSTED LRVKQQAANY GRLRHAQSRS MNDIADTPST
DQLKNKFMKK IPRDAEASNV LVGEVDFLNK PFVAFVRLAQ ATTLGGLTEV PVPTRFLFIL
LGPQGKAKSY NEIGRAIATL MVDDLFSDVA YKARDREDLI AGIDEFLDEV IVLPPGEWDP
KIRIEPPKKV PTADKRKSVF SLNELGQMNG TAGKGGGLSE DEEMPAPHEL GEELAFTGRF
CGGLYLDIKR KLPFLPSDFY EGFHIQSISA VLFIYLGCIT NAITFGGLLG DATDNYQGVM
ESFLGTALAG SVFCLFGGQP LIILSSTGPI LIFEKLLFEF SKNNGIDYME LRLWIGIHSC
LQCFILVASD ASYIIKYMTR FTEEGFSSLI SFIFISDAIK KMVGSFKYYP INTDFQPDYV
TTYKCECLAP DPTLDWSQLS KKECLKYGGS LVGKSCKYVP DLALMSFILF FGTYSMTVSL
KKFKFSRYFP TKLRKLISDF SIFMSIMTFV GLDMLVGLKT PKLIVPTEFK PTRPGRGWLV
MPFGKNPWWI YLASFVPALL VTILIFMDQQ ISAVIVNRKE NKLKKGCGYH LDLFWVGVLM
AACSFLGLPW YVAATVISIA HIDSLKMESE SSAPGEQPQF LGVREQRVTG ILVFVLTGVS
IFLAPILKFI PMPVLYGVFL YMGVASLSGI QFWDRIKLYL MPSKHQPDFT YLRHVPLRRV
HLFTLIQIIC LAVLWVLKST FLAIIFPVMI LGLMVVRKVL DMMFSQHDLA WLDDLLPEKE
KKKKEDDKKK RKDKEKKKPK ADDSEEEEKY HGYSNHSPSS ESDLDRSITL HLKISCPSSP
AMPMGRGMAC PVPQVKIEME SDYDSDMDRH RGRDISSETT L
//
