ID A0A3P9PLT6_POERE Unreviewed; 1363 AA.
AC A0A3P9PLT6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Nuclear factor of activated T-cells 5-like {ECO:0000313|Ensembl:ENSPREP00000022764.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000022764.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000022764.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000022764.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSPRET00000023001.1; ENSPREP00000022764.1; ENSPREG00000015325.1.
DR GeneTree; ENSGT00940000155213; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000015325; Expressed in head.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd07882; RHD-n_TonEBP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR015646; NFAT5_RHD_DNA-bd.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF10; NUCLEAR FACTOR OF ACTIVATED T-CELLS 5; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 275..444
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 18..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1261..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 804..834
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 20..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1363 AA; 146110 MW; 1A06891D1C5BA2B8 CRC64;
MFSCSPFMAE SVYDLLPKEL QLQPSSTQTD PPTMSQKSGG EAGPPPSATL ASDATSSTSS
PSASSSLAMG LSTSSSDHLT VSQHLHSTGA DGQGASEMQG MEATGSAPSR GGGASTAGGD
GGTGVLSGLG VQQLQNTPSK RRPVLSISPP PEDLFDDSQM SCQEEPAVAA AACPDSEHSS
SMWADDSVSN FSIISSVSYN DNTEVPRKSR KRTPRQRPGP KPTPPEDSMD VFDADSAKGP
HFVLSQLSTD KTSSIASSLD SGTVVKSGSL SAQFPQRSDG KELKILVQPE TQHRARYLTE
GSRGSVKDRT QQGFPTVKLE GISEPVVLQV FVANDAGRVK PHGFYQACRV TGRNTTACKE
VDIDGTTVIE IPLEPSNDMT LAVDCVGILK LRNADVEARI GVAGSKKKST RARLAFRVNI
PQPDGSVLTL QVPSSPILCT QPAGLPEILK KSLHSGSVKG GEEVFIIGKN FLKGTKVIFQ
ENIADDNSWQ AEAKIDTDLF HQNHLVVTVP PFHSQSITSP VSVGIFVMTN AGRSHEAQAF
IYTPESADSS SGQTVKTEGA SLVNTCIFDG QIKSVSSEQS DCSGQPSKRQ EDTPMEVSSN
PQPTDVFKPS PDPLISVQQT LELNSSPHPG GEAFESPMPL QPEDVELPQA PPVFPSLESL
STIQKQEISS TTSFPVSGDT TIPPVTPEVP QQFLRDPQES LSPESSDNSG TIVVVAMPQM
AAPAQPPPQQ TQVDLFPHEG VAQLERAVRE LQAGGTTTLE QVLEVAQQQL NSVLYSPAPS
AESLQQHVQE NMNSLRLGNS DGSLSQYQQQ QQILENLQQQ QQQQQQQQQL QQQVLSNMQI
QQQLMLQPQD QQQLQQQQMM ENIQQQQLQQ NQQQQVLNNI QLQDQQQQNQ ILSNLQEQQV
LEKLQQQLQA ELLQPQMHSS PQAQQPVSLL QQAGELLTIQ TSFPTPPPSH TSPPQQLFQS
PQPLAETQSS QQQVQATLLQ NTLTVLSGGG LGSEQQPTGS TIFLSTNPQP QQPQQQPQLA
FISSMETSSS QPQPVSMFQN QPPTQLSQPM EQQQSPQQNQ QPPQQHPLGQ QGTLFQSIPN
HSQASAIPQN QIAQPQQTGL LLCTSDLLFT TPAQAAPPIA GISVGIPQPD AAEPMSFQVQ
SSSGSSAASA ANQQQSLFQE QQPMQVTPSS GQVPNSQPVK LFIPQTSLSG LQGTIGSQEL
NTEAAAPTAT IFVVQGGVGV VASPGQQPPE QLFQTAVGGT VAPQGQPNLF VFGIQNDSSQ
LLSSSGPNLP AQTQAQNSNH MQPLLDQPMP QASPSMHSNL QNTLQAQMQT SLENALQSNT
QTPMQTSLQT QIQSSLQNQM QATISATSDM DKIEDILESL QKQ
//
