ID A0A3P9PMR2_POERE Unreviewed; 878 AA.
AC A0A3P9PMR2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=LDL receptor related protein 12 {ECO:0000313|Ensembl:ENSPREP00000023040.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000023040.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000023040.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000023040.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00037878}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A3P9PMR2; -.
DR STRING; 8081.ENSPREP00000023040; -.
DR Ensembl; ENSPRET00000023277.1; ENSPREP00000023040.1; ENSPREG00000015540.1.
DR GeneTree; ENSGT00940000158307; -.
DR OMA; YTCIPES; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000015540; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF47; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 12; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 5.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 59..171
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 266..379
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 631..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 178..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 185..203
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 197..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 246..261
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 402..417
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 440..455
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 458..470
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 465..483
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 477..492
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 878 AA; 96160 MW; A0E73F4C9551C29B CRC64;
MCCSVFPPFL PGCIASSQRN DNVYVSGFSN GAFRGSRLSV FSGSCGEAVT ETSSLRAACG
DVAELLRASS GVITSPGWPF QYPARLNCSW NIRARPGDSI TISFQDFDLQ GSHRCTSDWM
SISSYRSLDG LRVCGSSLPP PYILSQDHVW IHFHSDDGLA GKGFRLSYIT GKPEASSCDV
DQFHCSNGKC IPDWWRCNSM DECGDNSDEE LCVDSPFSFQ PCNLNQFPCL SRYTRIYTCL
PHSLRCDGSI DCQDLGDEID CDVPTCGEWL RNFYGSFSSP NYPDFYPPGS NCTWMIDTGD
HRKVILRFTD FKLDGTGYGD YVKVYDGLEE NPRRLLRVLT AFDSRAPVAV VSSSGQLRVH
FYADKINAAR GFNVTYQVDG FCLPWEVPCG GNWGCYTEQQ RCDGYWHCPN GRDELNCSSC
QEDEFPCSRN GACYPRSDRC NYQNRCPNGS DEKNCFFCQP GNFHCKNNRC VFESWVCDAQ
DDCGDGSDEE SCPIIVPTRV ITAAVIGSLI CGLLLVIALG CTCKLYSLRM FERRSFETQL
SRVEAELLRR EAPPSYGQLI AQGLIPPVED FPVCSGNQAS VLENLRQAVR SQLGFTSIRL
PSSGRHRNLW RRLFTFSRSR RSGSLALVSA DLEDSSGTGS TGSSGSDLLS PDSDDTDTEG
ERGRGVGAVG GPVAALPNKT PPPSAVEAVV SVASTPSRDR PRETPPPSSP VTVVTSSSDP
EVSEPQPPSS TALQRLAQNL HRLARNLTRT NQNQQNQPWT NQSPLRQLEA GRNGPEAAER
RGSREEEEDV ELLIPVSDSD SSSSSSSSLS DIRQPLLEPH PSCAAGPVHH HHRGASGRGG
RDGTCEHCGM VHTAQIPDAC LEATGKTESS DDELLLLC
//
