ID A0A3P9PNR3_POERE Unreviewed; 514 AA.
AC A0A3P9PNR3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000023517.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000023517.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000023517.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR STRING; 8081.ENSPREP00000023517; -.
DR Ensembl; ENSPRET00000023758.1; ENSPREP00000023517.1; ENSPREG00000015852.1.
DR GeneTree; ENSGT00390000010463; -.
DR OMA; EYQQDWK; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000015852; Expressed in head.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.10.238.210; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR HAMAP; MF_00313; Glutaminase; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR InterPro; IPR041541; Glutaminase_EF-hand.
DR NCBIfam; TIGR03814; Gln_ase; 1.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF33; GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL; 1.
DR Pfam; PF17959; EF-hand_14; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 10..93
FT /note="Glutaminase EF-hand"
FT /evidence="ECO:0000259|Pfam:PF17959"
SQ SEQUENCE 514 AA; 57756 MW; 6494A29AC6287148 CRC64;
MHSTSPSSGV ENMLFYTITE GRDQVPISYF NAALKKTGLQ PSDPRLRECM EKLRRTVTDS
VGEVMMDRDL FHRCVGGNIV LLIQAFRKKF IIPEFDVFAE KINEIYKTVQ EQSDGKVADY
IPQLAKFSPE LWGVSLCTVD GQRHSVGDTK QPFCLQSCVK PLQYAIAVHE SGTEKVHNYV
GMEPSGLKFN VLSLDEEDKP HNPMVNAGAI LISSLIKPFS NKAEKFDYVM EFVKKMAGQE
YVGFSNATFQ SEKETGDRNF AIGYYMKEKK CFPPGADMID ALDFYFQLCS IEVSCESGSV
MAATLANGGI CPITGERVLS AEAVRNTLSL MHSCGMYDFS GQMAFHVGLP AKSGVSGAIL
LVIPNVMGVM CWSPPLDRVG NSVRGIHFCE ELVSQFNFHN YDNLRHFVKK QDPRRQDGDD
RNKSVFNLMF AAFSGDVSAL RRYXKLWLLF VLGFSLAFDV HRGLFRNISX ICNYMCTYKH
ECMQTQTKTT CICIDSACLQ YRIAIFVFCL MSKV
//
